Andrew Quigley

Structure of a pH-sensitive pentameric ligand-gated ion channel from the Sarcoptes scabies mite

This study determines the structure of a pH-sensitive ion channel from the scabies mite and shows how ivermectin modulates its activity through pH-dependent conformational changes.

Structural insights into Pseudomonas aeruginosa lysine-specific uptake mechanism for extremely low pH regulation

The paper reports the cryo-EM structure of Pseudomonas aeruginosa LysP bound to lysine and a nanobody, revealing its transport mechanism and inhibition by L-4-thialysine.

C-terminal domain mobility underpins substrate engagement by the Chaetomium thermophilum EDEM:PDI ERAD-L checkpoint complex

The paper determines Cryo-EM structures of the EDEM:PDI complex with and without a substrate, revealing how disulfide bonds regulate conformational changes essential for substrate engagement.

The two crystal structures of unloaded and cargo-loaded Vacuolar Sorting Receptor 1 lumenal domain (VSR1-Nt) reveal two cargo binding sites and a mechanism of transport.

The paper determines the crystal structures of unloaded and cargo-loaded VSR1-Nt, revealing two cargo binding sites and a calcium-dependent mechanism for cargo binding and release.

A unique lower X-gate in TASK channels traps inhibitors within the vestibule

This paper reveals the structure of TASK-1 channels, identifying a unique lower X-gate that traps inhibitors in the vestibule, explaining their slow washout and pharmacological properties.