The paper develops orthogonal quorum sensing circuits in yeast using LuxR-type systems to enable programmable intercellular communication for synthetic biology applications.

ACS Synthetic Biology · Oct 9, 2026Peer-reviewedSynthetic Biology

Mycol: A user-friendly app for automating analysis of microscopy images

Samuel A. Bradley, Henry Emanuel Webel, Giovanni Schiesaro, Marcel Skumantz, Olga Novillo-Sanjuan, Alexandra Panagou, Rafael Lucena Marín, Emil Damgaard Jensen, Antonio Di Pietro, Carlos G. Acevedo‐Rocha

Mycol provides an accessible, open-source platform for microscopy image analysis using machine learning, enabling non-specialists to perform segmentation, classification, and quality control with minimal setup.

bioRxiv · Jun 5, 2026 · PreprintBioinformatics

Engineered yeast cells simulating CD19+ cancers to control CAR T cell activation

Marcus Deichmann, Giovanni Schiesaro, Keerthana Ramanathan, Katrine Zeeberg, Nanna M. T. Koefoed, Maria Ormhøj, Rasmus U. W. Friis, Ryan T. Gill, Sine Reker Hadrup, Emil D. Jensen, Michael Krogh Jensen

The paper presents a yeast-based system to simulate CD19+ cancers for controlled CAR T cell activation and evaluates antigen density effects.

Nature Communications · Nov 21, 2025Peer-reviewedSynthetic Biology

A yeast mating platform for multiplex screening of fungal GPCR-ligand interactions

Giovanni Schiesaro, Melani Mariscal, Mathias Jönsson, Ricardo Tenente, Mathies Brinks Sørensen, Marcus Wäneskog, María Victoria Aguilar Pontes, Agustina Undabarrena, Marcus Deichmann, Emma Elise Hoch-Schneider, Vijayalakshmi Kandasamy, Thomas M. Frimurer, Antonio Di Pietro, Line Katrine Harder Clemmensen, Michael Krogh Jensen, Emil D. Jensen

The paper develops a yeast mating platform to screen fungal GPCR-ligand interactions and identifies peptides that modulate fungal communication.

Proceedings of the National Academy of Sciences · Oct 24, 2025Peer-reviewedSynthetic Biology

Heat pre-treatment reduces multiplicity of plasmid transformations in yeast during electroporation, without diminishing the transformation efficiency

Marcus Wäneskog, Emma Elise Hoch-Schneider, Shilpa Garg, Christian Kronborg Cantalapiedra, Elena Schäfer, Michael Krogh Jensen, E. Damgaard Jensen

The paper introduces a method to reduce plasmid transformation multiplicity in yeast during electroporation, improving mono-transformation rates without reducing efficiency.

mBio · Dec 20, 2024Peer-reviewedMicrobiology

Labels as a Feature: Network Homophily for Systematically Discovering human GPCR Drug-Target Interactions

Frederik G. Hansson, Niklas Gesmar Madsen, Lea G. Hansen, Tadas Jakočiūnas, Bettina Lengger, Jay D. Keasling, Michael Krogh Jensen, Carlos G. Acevedo‐Rocha, Emil D. Jensen

The paper introduces a model called CSNN that uses network homophily to improve in-distribution predictions of drug-target interactions for human GPCRs.

bioRxiv · Mar 29, 2024 · PreprintBioinformatics

Integrating continuous hypermutation with high-throughput screening for optimization of cis,cis-muconic acid production in yeast

Emil D. Jensen, Francesca Ambri, Marie B. Bendtsen, Alex A. Javanpour, Chang C. Liu, Michael Krogh Jensen, Jay D. Keasling

The paper develops a directed evolution workflow combining OrthoRep and a transcription factor-based biosensor to optimize cis,cis-muconic acid production in yeast, achieving >13-fold higher titers.

Microbial Biotechnology · Mar 1, 2021Peer-reviewedSynthetic Biology