H. Ueno

Immunological landscape of human lymphoid explants during measles virus infection

The paper infects human lymphoid explants with measles virus and uses scRNA-Seq and flow cytometry to identify B cell preference and T cell resistance, along with ISG protein induction.

Direct Observation of Stepping Rotation of V-ATPase Reveals Rigid Coupling between Vo and V1 Motors

The paper observes ATP-driven stepping rotation of V-ATPase mutants using a gold nanoparticle probe, revealing rigid coupling between Vo and V1 motors through distinct pausing positions and step dynamics.

Genetic perturbation enhances functional heterogeneity in alkaline phosphatase

This study quantifies functional heterogeneity in wild-type and mutant alkaline phosphatase, finding that genetic perturbations increase heterogeneity and correlate with promiscuous activities.

The six steps of the F1-ATPase rotary catalytic cycle

This study determines the structure of the binding dwell state of F1-ATPase and provides a structural basis for the entire rotary catalysis cycle.

Elucidation and control of low and high active populations of alkaline phosphatase molecules for quantitative digital bioassay

This study quantitatively analyzes single-molecule ALP activity, revealing two distinct populations with different catalytic properties and demonstrating methods to generate homogeneous ALP populations.

Highly reliable, targeted photothermal cancer therapy combined with thermal dosimetry using indocyanine green lactosome

This paper demonstrates that ICG lactosome-assisted photothermal therapy with controlled thermal dosimetry can reliably cure tumors when temperatures reach 43°C or higher.

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals

Anti-α4β7 therapy reduces lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals with mild inflammatory bowel disease.

Evaluation of variability in high resolution protein structures by global distance scoring

This study evaluates variability in high-resolution protein structures using intramolecular distance scoring to enable global comparison of dynamics across proteins and species.