Author

E. J. Fay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Evolutionary Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Assay:cryo-EM· 1 Organism:multiple species· 1

Frequent Co-Authors

M. D. Daugherty· 3 shared A. C. Nelson· 1 shared A. E. Leschziner· 1 shared A. M. Dickey· 1 shared A. P. Ryan· 1 shared B. Auch· 1 shared B. V. Tsu· 1 shared C. M. Beierschmitt· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersEvolutionary Biology

M. D. Daugherty

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Author profile →

4 papers

Recent·Most cited

Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

E. J. Fay, K. Isterabadi, C. M. Rezanka, J. Le, M. D. Daugherty

The paper analyzes the evolutionary and functional roles of RIPK3 and its RHIM domain across vertebrates, finding that RHIM diversity tunes NF-κB activation while preserving cell death function.

bioRxiv · May 9, 2024Evolutionary Biology

Structure of LRRK1 and mechanisms of autoinhibition and activation

J. M. Reimer, A. M. Dickey, Y. X. Lin, R. G. Abrisch, S. Mathea, D. Chatterjee, E. J. Fay, M. D. Daugherty, S. L. Reck-Peterson, A. E. Leschziner

This study solves cryo-EM structures of LRRK1 in monomeric and dimeric forms, revealing distinct autoinhibition mechanisms compared to LRRK2 and their evolutionary context.

bioRxiv · Nov 22, 2022Biochemistry

Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome

B. V. Tsu, R. Agarwal, N. S. Gokhale, J. Kulsuptrakul, A. P. Ryan, L. K. Castro, C. M. Beierschmitt, E. A. Turcotte, E. J. Fay, R. E. Vance, J. L. Hyde, R. Savan, P. S. Mitchell, M. D. Daugherty

This study identifies CARD8 as a sensor for viral proteases, showing it activates inflammasomes in response to coronavirus 3CLpro and can be modulated by genetic variation.

bioRxiv · Sep 21, 2022Immunology

Analytical Validation of a COVID-19 qRT-PCR Detection Assay Using a 384-well Format and Three Extraction Methods

A. C. Nelson, B. Auch, M. Schomaker, D. M. Gohl, P. Grady, D. Johnson, R. Kincaid, K. E. Karnuth, J. Daniel, J. K. Fiege, E. J. Fay, T. Bold, R. A. Langlois, K. B. Beckman, S. Yohe

This study validates a qRT-PCR assay for SARS-CoV-2 detection using a 384-well format and three extraction methods, showing robust accuracy and sensitivity with commercial reagents.

bioRxiv · Apr 2, 2020 · PreprintPathology