Author

P. S. Mitchell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 3 Assay:proteomics· 2 Organism:mouse· 1

Frequent Co-Authors

R. E. Vance· 3 shared A. P. Ryan· 2 shared B. V. Tsu· 2 shared C. F. Lesser· 2 shared E. A. Turcotte· 2 shared L. Goers· 2 shared M. D. Daugherty· 2 shared R. Agarwal· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

R. E. Vance

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome

A. R. Kroken, K. A. Klein, P. S. Mitchell, V. Nieto, E. J. Jedel, D. J. Evans, S. M. J. Fleiszig

This study shows that Pseudomonas aeruginosa suppresses the caspase-4 inflammasome to enable intracellular replication in epithelial cells, highlighting a new role for ExoS in inhibiting host cell death.

bioRxiv · Feb 13, 2023 · PreprintMicrobiology

Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome

B. V. Tsu, R. Agarwal, N. S. Gokhale, J. Kulsuptrakul, A. P. Ryan, L. K. Castro, C. M. Beierschmitt, E. A. Turcotte, E. J. Fay, R. E. Vance, J. L. Hyde, R. Savan, P. S. Mitchell, M. D. Daugherty

This study identifies CARD8 as a sensor for viral proteases, showing it activates inflammasomes in response to coronavirus 3CLpro and can be modulated by genetic variation.

bioRxiv · Sep 21, 2022Immunology

Diverse viral proteases activate the NLRP1 inflammasome

B. V. Tsu, C. Beierschmitt, A. P. Ryan, R. Agarwal, P. S. Mitchell, M. D. Daugherty

This study identifies viral proteases from picornaviruses that activate human NLRP1 inflammasome through specific cleavage, revealing a host-specific immune response mechanism.

bioRxiv · Oct 16, 2020Microbiology

NAIP-NLRC4-deficient mice are susceptible to shigellosis

P. S. Mitchell, J. L. Roncaioli, E. A. Turcotte, L. Goers, R. A. Chavez, A. Y. Lee, C. F. Lesser, I. Rauch, R. E. Vance

This study shows that NAIP-NLRC4-deficient mice are susceptible to Shigella infection, mimicking human shigellosis, and reveals that inflammasome-mediated cell death protects against the disease.

bioRxiv · May 16, 2020Microbiology

Functional degradation: a mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

A. Sandstrom, P. S. Mitchell, L. Goers, E. W. Mu, C. F. Lesser, R. E. Vance

The paper identifies proteasome-mediated degradation of NLRP1B as a mechanism by which two distinct pathogen enzymes activate the inflammasome.

bioRxiv · Nov 6, 2018Immunology