Author

J. Kulsuptrakul

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Approach:genetic perturbation / CRISPR· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. S. Puschnik· 3 shared M. Ott· 2 shared R. Wang· 2 shared A. M. Ngo· 1 shared A. P. Ryan· 1 shared B. V. Tsu· 1 shared C. M. Beierschmitt· 1 shared C. R. Simoneau· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersMicrobiology

A. S. Puschnik

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Author profile →

5 papers

Recent·Most cited

A human-specific motif facilitates CARD8 inflammasome activation after HIV-1 infection

J. Kulsuptrakul, E. Turcotte, M. Emerman, P. Mitchell

The paper identifies a human-specific CARD8 motif that is cleaved by HIV-1 protease, leading to inflammasome activation and pyroptosis after HIV-1 infection.

bioRxiv · Oct 4, 2022Microbiology

Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome

B. V. Tsu, R. Agarwal, N. S. Gokhale, J. Kulsuptrakul, A. P. Ryan, L. K. Castro, C. M. Beierschmitt, E. A. Turcotte, E. J. Fay, R. E. Vance, J. L. Hyde, R. Savan, P. S. Mitchell, M. D. Daugherty

This study identifies CARD8 as a sensor for viral proteases, showing it activates inflammasomes in response to coronavirus 3CLpro and can be modulated by genetic variation.

bioRxiv · Sep 21, 2022Immunology

Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses

R. Wang, C. R. Simoneau, J. Kulsuptrakul, M. Bouhaddou, K. Travisano, J. M. Hayashi, J. Carlson-Stevermer, J. Oki, K. Holden, N. J. Krogan, M. Ott, A. S. Puschnik

The paper identifies host factors and pathways common to SARS-CoV-2 and common cold coronaviruses using CRISPR screens, revealing shared and unique factors that support viral infection.

bioRxiv · Sep 24, 2020Microbiology

A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection

J. Kulsuptrakul, R. Wang, N. L. Meyers, M. Ott, A. S. Puschnik

bioRxiv · Dec 15, 2019Microbiology

The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins

A. M. Ngo, M. J. Shurtleff, K. D. Popova, J. Kulsuptrakul, J. S. Weissman, A. S. Puschnik

This study shows the ER membrane protein complex is essential for correct topology and stable expression of flavivirus polyproteins by preventing degradation of NS4A-NS4B.

bioRxiv · Sep 4, 2019Microbiology