Author

M. D. Daugherty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Assay:cryo-EM· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. P. Ryan· 3 shared B. V. Tsu· 3 shared E. J. Fay· 3 shared C. Beierschmitt· 2 shared P. S. Mitchell· 2 shared R. Agarwal· 2 shared S. L. Reck-Peterson· 2 shared A. E. Leschziner· 1 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMicrobiology

A. P. Ryan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

E. J. Fay, K. Isterabadi, C. M. Rezanka, J. Le, M. D. Daugherty

The paper analyzes the evolutionary and functional roles of RIPK3 and its RHIM domain across vertebrates, finding that RHIM diversity tunes NF-κB activation while preserving cell death function.

bioRxiv · May 9, 2024Evolutionary Biology

Structure of LRRK1 and mechanisms of autoinhibition and activation

J. M. Reimer, A. M. Dickey, Y. X. Lin, R. G. Abrisch, S. Mathea, D. Chatterjee, E. J. Fay, M. D. Daugherty, S. L. Reck-Peterson, A. E. Leschziner

This study solves cryo-EM structures of LRRK1 in monomeric and dimeric forms, revealing distinct autoinhibition mechanisms compared to LRRK2 and their evolutionary context.

bioRxiv · Nov 22, 2022Biochemistry

SARS-CoV-2 Uses Nonstructural Protein 16 to Evade Restriction by IFIT1 and IFIT3

C. Schindewolf, K. Lokugamage, M. Vu, B. A. Johnson, D. Scharton, J. A. Plante, B. K. Kalveram, P. A. Crocquet-Valdes, S. L. Sotcheff, E. Jaworski, R. E. Alvarado, K. Debbink, M. D. Daugherty, S. Weaver, A. L. Routh, , V. D. Menachery

This paper shows that SARS-CoV-2's NSP16 protein helps evade immune detection by methylating viral mRNA, and disrupting this function reduces viral replication and disease in hamsters.

bioRxiv · Sep 26, 2022Microbiology

Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome

B. V. Tsu, R. Agarwal, N. S. Gokhale, J. Kulsuptrakul, A. P. Ryan, L. K. Castro, C. M. Beierschmitt, E. A. Turcotte, E. J. Fay, R. E. Vance, J. L. Hyde, R. Savan, P. S. Mitchell, M. D. Daugherty

This study identifies CARD8 as a sensor for viral proteases, showing it activates inflammasomes in response to coronavirus 3CLpro and can be modulated by genetic variation.

bioRxiv · Sep 21, 2022Immunology

Antiviral function and viral antagonism of the rapidly evolving dynein activating adapter NINL

D. A. Stevens, C. Beierschmitt, S. Mahesula, M. R. Corley, J. Salogiannis, B. V. Tsu, B. Cao, A. P. Ryan, S. L. Reck-Peterson, M. D. Daugherty

This study identifies NINL as an antiviral innate immune component targeted by viruses through proteolytic cleavage, revealing its role in interferon response and viral antagonism.

bioRxiv · Jul 11, 2022Microbiology

Diverse viral proteases activate the NLRP1 inflammasome

B. V. Tsu, C. Beierschmitt, A. P. Ryan, R. Agarwal, P. S. Mitchell, M. D. Daugherty

This study identifies viral proteases from picornaviruses that activate human NLRP1 inflammasome through specific cleavage, revealing a host-specific immune response mechanism.

bioRxiv · Oct 16, 2020Microbiology