Author

E. M. Denham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

M. I. Barton· 3 shared P. A. van der Merwe· 3 shared J. Goyette· 2 shared R. L. Paterson· 2 shared A. Lloyd· 1 shared A. M. Morch· 1 shared A. Patel· 1 shared A. W. Purcell· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersImmunology

M. I. Barton

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Ligand requirements for immunoreceptor triggering

M. I. Barton, R. L. Paterson, E. M. Denham, J. Goyette, P. A. van der Merwe

This study investigates ligand requirements for NTR triggering by varying ligand length, mobility, and valency, finding that size-based segregation, not clustering or mechanical force, is more consistent with the kinetic-segregation model.

bioRxiv · Sep 11, 2023Immunology

Conserved allomorphs of MR1 drive specificity of MR1-restricted TCRs

T. V. Cornforth, N. A. Moyo, S. Cole, E. Lam, T. Lobry, R. Wolchinsky, A. Lloyd, K. Ward, E. M. Denham, G. S. Besra, N. Veerapen, P. T. Illing, J. P. Vivian, J. M. Raynes, J. Le Nours, , J. Dukes

The paper shows that MR1-restricted TCRs recognize an allelic variant of MR1 (MR1*04) present in healthy individuals, indicating that these TCRs are not cancer-specific and may react to both cancer and healthy cells.

bioRxiv · Jul 17, 2023Cancer Biology

Using CombiCells, a platform enabling titration and combinatorial display of cell surface ligands, to study T cell antigen sensitivity by TCRs, CARs, and BiTEs

A. Patel, V. Andre, S. Bustamante Eguiguren, M. I. Barton, J. Burton, E. M. Denham, J. Pettmann, A. M. Morch, M. Kutuzov, J. A. Siller-Farfan, M. L. Dustin, P. A. van der Merwe, O. Dushek

The paper uses CombiCells to compare T cell antigen sensitivity mediated by TCRs, CARs, and BiTEs and assess the impact of co-stimulation and co-inhibition receptors.

bioRxiv · Jun 15, 2023 · PreprintImmunology

A generic cell surface ligand system for studying cell-cell recognition

E. M. Denham, M. I. Barton, S. M. Black, M. J. Bridge, B. de Wet, R. L. Paterson, P. A. van der Merwe, J. Goyette

This paper introduces a generic cell surface ligand system to manipulate ligand density, valency, dimensions, and affinity for studying cell-cell recognition.

bioRxiv · Feb 11, 2019Immunology