Author

E. M. Lewandowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:structural biology· 2 Organism:C. elegans· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. Wang· 2 shared X. ZhangiD· 2 shared Y. Chen· 2 shared H. Tan· 1 shared J. A. Townsend· 1 shared J. R. Gatdula· 1 shared J. S. Choy· 1 shared L. M. Jacobs· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPharmacology & Toxicology

J. Wang

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2 papers

Recent·Most cited

Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir

Y. Hu, E. M. Lewandowski, H. Tan, R. T. Morgan, X. Zhang, L. M. Jacobs, S. G. Butler, M. V. Mongora, J. S. Choy, Y. Chen, J. Wang

The study identifies SARS-CoV-2 Mpro mutations associated with nirmatrelvir resistance from clinical isolates.

bioRxiv · Jun 28, 2022Pharmacology & Toxicology

A unique class of Zn2+-binding PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile

M. D. Sacco, S. Wang, S. R. Adapa, X. Zhang, M. V. Gongora, J. R. Gatdula, E. M. Lewandowski, L. R. Hammond, J. A. Townsend, M. T. Marty, J. Wang, P. J. Eswara, R. H. Y. Jiang, X. Sun, Y. Chen

This study identifies PBP2 as the primary target of cephalosporins in C. difficile and reveals a unique Zn2+-binding motif in PBP2 and related PBPs that contributes to cephalosporin resistance and sporulation.

bioRxiv · Jan 4, 2022 · PreprintMicrobiology