Author

J. A. Townsend

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 3 Biochemistry· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 3 Assay:structural biology· 2 Organism:C. elegans· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Organism:virus· 1

Frequent Co-Authors

M. T. Marty· 6 shared J. Wang· 5 shared C. Ma· 3 shared M. D. Sacco· 3 shared X. ZhangiD· 3 shared Y. Chen· 3 shared Y. Hu· 3 shared A. Kolocouris· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersBiophysics

M. T. Marty

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Differences in Oligomerization of the SARS-CoV-2 Envelope Protein, Poliovirus VP4, and HIV Vpu

J. A. Townsend, O. Fapohunda, Z. Wang, H. Pham, M. T. Taylor, B. Kloss, S. H. Park, S. J. Opella, C. A. Aspinwall, M. T. Marty

The paper uses native mass spectrometry to analyze the oligomerization states of SARS-CoV-2 E protein, poliovirus VP4, and HIV Vpu, revealing differences in their assembly patterns.

bioRxiv · Aug 18, 2023Biophysics

A unique class of Zn2+-binding PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile

M. D. Sacco, S. Wang, S. R. Adapa, X. Zhang, M. V. Gongora, J. R. Gatdula, E. M. Lewandowski, L. R. Hammond, J. A. Townsend, M. T. Marty, J. Wang, P. J. Eswara, R. H. Y. Jiang, X. Sun, Y. Chen

This study identifies PBP2 as the primary target of cephalosporins in C. difficile and reveals a unique Zn2+-binding motif in PBP2 and related PBPs that contributes to cephalosporin resistance and sporulation.

bioRxiv · Jan 4, 2022 · PreprintMicrobiology

Influenza A M2 Channel Oligomerization is Sensitive to its Chemical Environment

J. A. Townsend, H. M. Sanders, A. D. Rolland, C. Park, N. Horton, J. S. Prell, J. Wang, M. T. Marty

This study shows that influenza A M2 forms various oligomers influenced by chemical environment, challenging the previous monodisperse tetramer model.

bioRxiv · May 7, 2021Biophysics

Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against Mpro and cathepsin L

M. D. Sacco, C. Ma, P. Lagarias, A. Gao, J. A. Townsend, X. Meng, P. Dube, X. Zhang, Y. Hu, N. Kitamura, B. Hurst, B. Tarbet, M. T. Marty, A. Kolocouris, Y. Xiang, , J. Wang

This study determines the structure of SARS-CoV-2 Mpro with calpain inhibitors and analogues, revealing new insights for developing dual inhibitors against Mpro and cathepsin L.

Science Advances · Dec 11, 2020Peer-reviewedBiophysics

Ebselen, disulfiram, carmofur, PX-12, tideglusib, and shikonin are non-specific promiscuous SARS-CoV-2 main protease inhibitors

C. Ma, Y. Hu, J. A. Townsend, P. Lagarias, M. T. Marty, A. Kolocouris, J. Wang

This study shows that six compounds inhibit SARS-CoV-2 Mpro non-specifically and their antiviral activity cannot be predicted by IC50 values in the absence of DTT.

bioRxiv · Sep 15, 2020Biochemistry

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

C. Ma, M. D. Sacco, B. Hurst, J. A. Townsend, Y. Hu, T. Szeto, X. Zhang, B. Tarbet, M. T. Marty, Y. Chen, J. Wang

This study identifies inhibitors of SARS-CoV-2 main protease that show potent antiviral activity in cell culture.

Cell Research · Jun 15, 2020Peer-reviewedPharmacology & Toxicology