M. T. Marty

Characterizing Adeno-Associated Virus Capsids with both Denaturing and Intact Analysis Methods

The paper combines two analytical methods to characterize AAV capsids and their subunits, evaluating capsid integrity and VP sequence variations across three serotypes.

Simultaneous Native Mass Spectrometry Analysis of Single and Double Mutants to Probe Lipid Binding to Membrane Proteins

This study uses native mass spectrometry to analyze single and double mutants of Aquaporin Z, revealing the energetic contributions of specific residues to cardiolipin binding.

Differences in Oligomerization of the SARS-CoV-2 Envelope Protein, Poliovirus VP4, and HIV Vpu

The paper uses native mass spectrometry to analyze the oligomerization states of SARS-CoV-2 E protein, poliovirus VP4, and HIV Vpu, revealing differences in their assembly patterns.

Identifying Membrane Protein-Lipid Interactions with Lipidomic Lipid Exchange-Mass Spectrometry

This paper introduces a method to identify lipid-protein interactions using lipidomic lipid exchange-mass spectrometry and applies it to study three membrane proteins.

Exposing the molecular heterogeneity of glycosylated biotherapeutics

This paper introduces a new method for analyzing glycoform heterogeneity in biotherapeutics using mass spectrometry and bioinformatics, showing its effectiveness in measuring proteoform diversity and correlating glycoform sub-populations with pharmacological properties.

A unique class of Zn2+-binding PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile

This study identifies PBP2 as the primary target of cephalosporins in C. difficile and reveals a unique Zn2+-binding motif in PBP2 and related PBPs that contributes to cephalosporin resistance and sporulation.

Investigating the Lipid Selectivity of Membrane Proteins in Heterogeneous Nanodiscs

This study uses native mass spectrometry to analyze lipid selectivity of membrane proteins AmtB and AqpZ in heterogeneous nanodiscs, revealing distinct lipid binding preferences.

Lipid Tails Modulate Antimicrobial Peptide Membrane Incorporation and Activity

This study investigates how lipid tail length and saturation affect antimicrobial peptide membrane incorporation and activity using mass spectrometry and leakage assays.

Influenza A M2 Channel Oligomerization is Sensitive to its Chemical Environment

This study shows that influenza A M2 forms various oligomers influenced by chemical environment, challenging the previous monodisperse tetramer model.

Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against Mpro and cathepsin L

This study determines the structure of SARS-CoV-2 Mpro with calpain inhibitors and analogues, revealing new insights for developing dual inhibitors against Mpro and cathepsin L.

Ebselen, disulfiram, carmofur, PX-12, tideglusib, and shikonin are non-specific promiscuous SARS-CoV-2 main protease inhibitors

This study shows that six compounds inhibit SARS-CoV-2 Mpro non-specifically and their antiviral activity cannot be predicted by IC50 values in the absence of DTT.

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

This study identifies inhibitors of SARS-CoV-2 main protease that show potent antiviral activity in cell culture.