Author

S. R. Adapa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

R. Jiang· 2 shared A. Borsky· 1 shared A. Lucky· 1 shared C. Downs· 1 shared C. Marinescu· 1 shared C. Wang· 1 shared E. Cornelius Ruhs· 1 shared E. M. Lewandowski· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

R. Jiang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Bacterial sepsis triggers stronger transcriptomic immune responses in larger primates

R. McMinds, R. H. Jiang, S. R. Adapa, E. Cornelius Ruhs, R. A. Munds, J. W. Leiding, C. Downs, L. B. Martin

This study finds that larger primates exhibit stronger transcriptomic immune responses to bacterial sepsis, supporting the Safety Factor hypothesis over the Metabolic Theory of Ecology.

bioRxiv · Jul 11, 2023Evolutionary Biology

Porphyrin overdrive rewires pan-cancer cell metabolism

S. R. Adapa, G. Hunter, N. Amin, C. Marinescu, A. Borsky, E. Sagatys, S. Sebti, G. Reuther, G. Ferreira, R. Jiang

This study identifies porphyrin overdrive as a universal metabolic rewiring in cancer cells, showing its role in oncogenic growth and demonstrating a novel 'bait-and-kill' strategy to target it.

bioRxiv · Feb 18, 2022 · PreprintCancer Biology

A unique class of Zn2+-binding PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile

M. D. Sacco, S. Wang, S. R. Adapa, X. Zhang, M. V. Gongora, J. R. Gatdula, E. M. Lewandowski, L. R. Hammond, J. A. Townsend, M. T. Marty, J. Wang, P. J. Eswara, R. H. Y. Jiang, X. Sun, Y. Chen

This study identifies PBP2 as the primary target of cephalosporins in C. difficile and reveals a unique Zn2+-binding motif in PBP2 and related PBPs that contributes to cephalosporin resistance and sporulation.

bioRxiv · Jan 4, 2022 · PreprintMicrobiology

A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum

J. MIAO, C. Wang, A. Lucky, X. Liang, H. Min, S. R. Adapa, R. Jiang, K. Kim, L. Cui

This study identifies a unique GCN5 histone acetyltransferase complex in Plasmodium falciparum that regulates erythrocyte invasion and virulence by modulating chromatin states and gene expression.

bioRxiv · Feb 3, 2021Microbiology