Author

G. D. Pintilie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 3 Research Focus:cell type annotation· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

W. Chiu· 4 shared K. Zhang· 3 shared M. F. Schmid· 3 shared S. Li· 3 shared A. Carfi· 1 shared A. Kryshtafovych· 1 shared A. M. Arvin· 1 shared A. P. Joseph· 1 shared

Activity by Year

2020-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersCell Biology

W. Chiu

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Author profile →

6 papers

Recent·Most cited

Cryogenic electron tomography reveals novel structures in the apical complex of Plasmodium falciparum

S. Y. Sun, L.-a. S. Zarko, G. D. Pintilie, C. Y. Kim, S. R. Staggers, M. F. Schmid, E. S. Egan, W. Chiu, J. C. Boothroyd

This study uses cryogenic electron tomography to reveal new structural details of the apical complex in Plasmodium falciparum merozoites, including interactions between rhoptries and other structures.

bioRxiv · Sep 14, 2022Cell Biology

The N-terminus of varicella-zoster virus glycoprotein B has a functional role in fusion.

S. L. Oliver, Y. Xing, D.-H. Chen, S. H. Roh, G. D. Pintilie, D. A. Bushnell, M. H. Sommer, E. Yang, A. Carfi, W. Chiu, A. M. Arvin

This study identifies the N-terminus of VZV glycoprotein B as critical for membrane fusion, showing that mutations in this region impair viral propagation.

bioRxiv · Sep 8, 2020Microbiology

Resolving Individual-Atom of Protein Complex using Commonly Available 300-kV Cryo-electron Microscopes

K. Zhang, G. D. Pintilie, S. Li, M. F. Schmid, W. Chiu

The paper demonstrates near-atomic resolution structure determination of apoferritin using single-particle cryo-EM with a 300-kV Titan Krios microscope, achieving 1.35 Å resolution and resolving heavy atoms and rotameric configurations.

bioRxiv · Aug 19, 2020Biophysics

Cryo-electron Microscopy and Exploratory Antisense Targeting of the 28-kDa Frameshift Stimulation Element from the SARS-CoV-2 RNA Genome

K. Zhang, I. N. Zheludev, R. J. Hagey, M. T.-P. Wu, R. Haslecker, Y. J. Hou, R. Kretsch, G. D. Pintilie, R. Rangan, W. Kladwang, S. Li, E. A. Pham, C. Bernardin, R. S. Baric, T. P. Sheahan, , R. Das

The paper uses cryo-EM and ASO experiments to study the SARS-CoV-2 FSE structure and its potential as an antiviral target, finding a complex tertiary structure but challenges in effective inactivation.

bioRxiv · Jul 18, 2020Biochemistry

Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution

C. L. Lawson, A. Kryshtafovych, P. D. Adams, P. Afonine, M. L. Baker, B. A. Barad, P. Bond, T. Burnley, R. Cao, J. Cheng, G. Chojnowski, K. Cowtan, K. A. Dill, F. DiMaio, D. Farrell, , Wan

The paper evaluates cryo-EM model quality using benchmark maps, showing high accuracy and reproducibility across 13 teams and recommending multiple metrics for model assessment.

bioRxiv · Jun 12, 2020Biochemistry

Molecular basis for the ATPase-powered substrate translocation by the Lon AAA+ protease

S. Li, K.-Y. Hsieh, S.-C. Su, G. D. Pintilie, K. Zhang, C.-I. Chang

The paper determines the cryo-EM structure of MtaLonA to elucidate its mechanism of ATP-powered substrate translocation.

bioRxiv · Apr 29, 2020Biophysics