Transcriptomic analysis reveals that severity of infectious bursal disease in White Leghorn inbred chicken lines is associated with greater bursal inflammation in vivo and more rapid induction of pro-inflammatory responses in primary bursal cells stimulated ex vivo.
A. S. Asfor, S. Nazki, V. R. Reddy, E. Campbell, K. L. Dulwich, E. S. Giotis, M. A. Skinner, A. J. Broadbent
This study compares the transcriptomic responses of inbred chicken lines to IBDV infection, finding that severe disease correlates with enhanced inflammation and faster pro-inflammatory gene induction in bursal cells.
bioRxiv · Mar 18, 2021Microbiology