PD-1 is induced on tumor-associated macrophages in obesity to directly restrain anti-tumor immunity
J. E. Bader, M. M. Wolf, M. Z. Madden, B. I. Reinfeld, E. N. Arner, E. S. Hathaway, K. K. Steiner, G. A. Needle, M. D. Landis, M. A. Cottam, X. Ye, A. Christofides, V. A. Boussiotis, S. M. Haake, K. E. Beckermann, , J. C. Rathmell
This study shows obesity induces PD-1 on tumor-associated macrophages, which suppresses anti-tumor immunity by altering metabolic and functional properties of these cells.
bioRxiv · Nov 12, 2022 · PreprintImmunology