Author

E. S. O'Brien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

B. K. Kobilka· 2 shared C. Zhang· 2 shared H. Wang· 2 shared K. K. Kumar· 2 shared Y. Shiimura· 2 shared A. El Daibani· 1 shared A. I. Basbaum· 1 shared A. J. Wand· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

B. K. Kobilka

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Negative allosteric modulation of the μ-opioid receptor

E. S. O'Brien, V. A. Rangari, A. El Daibani, S. O. Eans, B. White, H. Wang, Y. Shiimura, K. Krishna Kumar, K. Appourchaux, W. Huang, C. Zhang, J. M. Mathiesen, T. Che, J. P. McLaughlin, S. Majumdar, B. K. Kobilka

This paper identifies a negative allosteric modulator of the μ-opioid receptor that blocks agonist activity and enhances naloxone efficacy, offering potential for safer opioid overdose reversal.

bioRxiv · Sep 8, 2023 · PreprintBiochemistry

Step-wise activation of a Family C GPCR

K. K. Kumar, H. Wang, C. Habrian, N. R. Latorraca, J. Xu, E. S. O'Brien, C. Zhang, E. Montabana, A. Koehl, S. Marqusee, E. Y. Isacoff, B. K. Kobilka

The paper proposes a step-wise activation model for metabotropic glutamate receptor subtype 5, supported by structural and fluorescence imaging data of different activation states.

bioRxiv · Aug 29, 2023 · PreprintBiophysics

Large library docking for cannabinoid-1 receptor agonists with reduced side effects

T. A. Tummino, C. Iliopoulos-Tsoutsouvas, J. M. Braz, E. S. O'Brien, R. M. Stein, V. Craik, N. K. Tran, S. Ganapathy, F. Liu, Y. Shiimura, F. Tong, T. C. Ho, D. S. Radchenko, Y. S. Moroz, S. R. Rosado, , B. K. Shoichet

The paper identifies a new cannabinoid-1 receptor agonist with reduced side effects through large library docking and experimental validation.

bioRxiv · Feb 27, 2023 · PreprintPharmacology & Toxicology

Membrane Proteins Have Distinct Fast Internal Motion and Residual Conformational Entropy

E. S. O'Brien, B. Fuglestad, H. J. Lessen, M. A. Stetz, D. W. Lin, B. S. Marques, K. Gupta, K. G. Fleming, A. J. Wand

This study characterizes the fast internal motion and residual conformational entropy of membrane proteins using solution NMR relaxation techniques, revealing unique dynamics compared to soluble proteins.

bioRxiv · Apr 2, 2020Biophysics