Author

Sergio Ortiz‐Espinosa

Fred Hutch Cancer CenterORCID 0000-0001-9192-2956Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

Amelia R. WilhelmiD· 1 shared Andrew J. SnyderiD· 1 shared Anna ElziD· 1 shared Annalyssa Long· 1 shared Asheema Khanna· 1 shared Ashmitha RajendraniD· 1 shared Carolyn ShashaiD· 1 shared Cyrus Michael GhajariD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperImmunology

Amelia R. WilhelmORCID

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Author profile →

2 papers

Recent·Most cited

SARS-CoV-2 S1 spike protein induces a temporal systemic immune response and promotes long-term anxiety-like behaviors

Leyre Merino-Galán, John Hemenway, Hawa Jagana, Taylor S. Jackson, Ashmitha Rajendran, Asheema Khanna, Sergio Ortiz‐Espinosa, Surojit Sarkar, Vandana Kalia, Siobhan S. Pattwell

This study investigates how SARS-CoV-2 S1 protein induces systemic immune responses and long-term anxiety-like behaviors in mice.

bioRxiv · Jun 18, 2026 · PreprintMolecular Biology

Modulating AP-1 enables CAR-T cells to establish an intratumoral PD-1+Tcf1+ stem-like reservoir and overcomes resistance to PD-1 axis blockade

Andrew J. Snyder, Sarah M. Garrison, Mitchell G. Kluesner, W. Sam Nutt, Carolyn Shasha, T. T. Giang Ho, Sydney A. Marsh, Miles Hamilton Linde, Feinan Wu, Lauren K. Meyer, Amelia R. Wilhelm, Sergio Ortiz‐Espinosa, Victor Zepeda, Emma Bingham, Haleema S. Malik, , Shivani Srivastava

This study shows that overexpressing c-Jun in CAR-T cells enhances their ability to maintain PD-1+Tcf1+ stem-like cells in tumors and improves response to PD-L1 blockade.

Science Immunology · Mar 6, 2026Peer-reviewedImmunology