Christopher T. Richie

Neuronal Grin2c expression and the cocaine engram: a medial prefrontal cortex substrate for conditioned place preference

This study identifies Grin2c expression in mPFC neurons as a molecular component of cocaine-induced conditioned place preference engrams.

Targeted gene transfer into developmentally defined cell populations of the primate brain

This paper introduces a method for targeted gene transfer into specific cell populations of the fetal primate brain using ultrasound-guided viral injections.

Generation and characterization of a tamoxifen-inducible, Cre driver rat for transgene expression in microglia

The paper describes the generation of a tamoxifen-inducible Cre driver rat for microglial transgene expression and validates its specificity and functionality.

A Rapid Method for Producing Adeno-Associated Viral Vectors Suitable for Transducing Rodent Neurons in vitro and in vivo

This paper introduces a simplified AAV packaging protocol that produces sufficient virus for testing in rodent CNS without requiring large equipment.

Excitotoxic glutamate levels cause the secretion of resident endoplasmic reticulum proteins

The paper shows that glutamate receptor activation causes ER Ca2+ depletion, leading to secretion of ER resident proteins and disrupting proteostasis during excitotoxicity.

Nucleus Accumbens Local Circuit for Cue-Dependent Aversive Learning

The paper identifies a nucleus accumbens local circuit where excitatory plasticity and substance P release are essential for cue-dependent aversive learning and recall.

Effect of selective lesions of nucleus accumbens μ-opioid receptor-expressing cells on heroin self-administration in male and female rats: a study with novel Oprm1-Cre knock-in rats

This study introduces a CRISPR-based Oprm1-Cre knock-in rat to investigate the role of nucleus accumbens MOR-expressing cells in heroin self-administration, finding sex-specific effects on acquisition and effort.