Carcinogen-induced DNA adducts amplify APOBEC mutagenesis through nucleotide excision repair
Cameron C. Durfee, Bojana Stefanovska, Rongjie Wu, J. Caballero, Mahmoud A. Ibrahim, Michael A. Carpenter, Liping Liu, Shuvro Prokash Nandi, Prokopios P. Argyris, Luca Boscolo Bielo, Eric C. L. Li, Nuri A. Temiz, Yufan Zhou, Erik N. Bergstrom, Christopher D. Mullally, , Reuben S. Harris
This study shows that carcinogen-induced DNA adducts enhance APOBEC3B-mediated mutagenesis, leading to increased mutation rates in cancer genomes.
bioRxiv · Jan 18, 2025 · PreprintCancer Biology