Y. Saeys

Corelative light and electron microscopy (CLEM) image registration by blood vessel axes alignment

This paper introduces a method for aligning blood vessel axes in CLEM images to improve registration accuracy.

Epigenomic programming of peripheral monocytes determines their transcriptional response to the tumor microenvironment

This study shows that peripheral monocytes' epigenomic landscape is rewired by a distal tumor, shaping their transcriptional response upon tumor infiltration.

Systemic autoimmune disease patients' blood immunome reveals specificities and commonalities among different diagnostic entities

The paper uses immunophenotyping to identify patient subgroups in systemic autoimmune diseases, revealing shared immunophenotypes and cytokine signatures across different diagnoses.

Transit amplifying cells balance growth and differentiation in above-ground meristems

The paper identifies transit amplifying cells in maize meristems using spatial transcriptomics and shows their growth and differentiation are independently controlled.

Cell type-specific attenuation of brassinosteroid signalling drives stomatal asymmetric cell division

The paper shows that BR signaling is attenuated in stomatal precursor cells but remains active in differentiating epidermal cells, mediated by scaffold proteins.

Single-cell molecular profiling using ex vivo functional readouts fuels precision oncology in glioblastoma

The paper introduces PROSPERO, a single-cell assay to evaluate therapy response in glioblastoma by measuring molecular drug responses in fresh tumor samples, revealing limited therapeutic capacity and cellular plasticity.

CD8 memory precursor cells generation is a continuous process

The paper identifies that memory precursor cells are continuously generated over time following acute infection, with increased numbers and effector gene expression observed later.

Spatial proteogenomics reveals distinct and evolutionarily-conserved hepatic macrophage niches

This study creates a spatial proteogenomic atlas of the liver across species, identifying conserved macrophage niches and their regulatory mechanisms.

Analysis of phloem trajectory links tissue maturation to cell specialization.

The paper reconstructs the protophloem developmental trajectory in Arabidopsis root cells to show how maturation gradients and transcription factors regulate cell specialization.

Deterministic scRNA-seq of individual intestinal organoids reveals new subtypes and coexisting distinct stem cell pools

The paper introduces DisCo, a deterministic scRNA-seq method for small tissue samples, revealing new intestinal organoid subtypes and stem cell populations.

Single cell profiling of immature human postnatal thymocytes resolves the complexity of intra-thymic lineage differentiation and thymus seeding precursors.

The paper uses single-cell RNA sequencing to analyze immature human thymocytes and identifies thymus seeding precursors and T-lineage developmental pathways.

A cell atlas of human thymic development defines T cell repertoire formation

This study creates a cell atlas of the human thymus using scRNA-seq, revealing new cell populations and insights into T-cell development and TCR recombination.

The CARD-CC/Bcl10/paracaspase signaling complex is functionally conserved since the last common ancestor of planulozoa.

This study identifies the ancient conservation of the CARD-CC/Bcl10/paracaspase signaling complex across planulozoa, including invertebrates and vertebrates.