PNPO-PLP Axis Senses Prolonged Hypoxia by Regulating Lysosomal Activity
H. Sekine, H. Takeda, A. Kishino, H. Anzawa, T. Isagawa, N. Ota, N. Kato, S. Kimura, Z. Liu, K. Kato, F. Katsuoka, M. Yamamoto, F. Miura, T. Ito, M. Takahashi, , H. Motohashi
The paper identifies the PNPO-PLP axis as a mechanism for sensing prolonged hypoxia by regulating lysosomal activity in macrophages, leading to altered inflammatory responses.
bioRxiv · Oct 28, 2022 · PreprintBiochemistry