Author

F. O'Connell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. A. Brugman· 1 shared A. B. Heeran· 1 shared A. Portela· 1 shared A. Rahman· 1 shared A. Villanueva· 1 shared B. N. Kennedy· 1 shared C. O. Maoldomhnaigh· 1 shared D. J. Cox· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

A. A. Brugman

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis dependent functional plasticity.

D. J. Cox, S. A. Connolly, C. O. Maoldomhnaigh, A. A. Brugman, O. S. Thomas, E. Duffin, K. M. Gogan, O. O Gallchobhair, D. M. Murphy, S. A. O'Rourke, F. O'Connell, P. Nadarajan, J. J. Phelan, L. E. Gleeson, S. A. Basdeo, J. Keane

This study shows that human airway macrophages reprogram their metabolism in response to IFN-γ, leading to glycolysis-dependent functional plasticity that differs from monocyte-derived macrophages.

bioRxiv · Mar 20, 2024Immunology

High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells.

K. Slater, A. B. Heeran, R. Sanz-Pamplona, H. Kalirai, A. Rahman, M. Helmi, S. Garcia-Mulero, F. O'Connell, R. Bosch, A. Portela, A. Villanueva, J. M. Piulats, W. M. Gallagher, L. D. Jensen, S. E. Coupland, , B. N. Kennedy

This paper shows high CysLT1 receptor expression in uveal melanoma correlates with poor survival and that CysLT1 antagonists inhibit tumor growth and alter cancer secretome and metabolism.

bioRxiv · Aug 23, 2020Cancer Biology