F. W. Huang

RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4

This study identifies RPL22 as a tumor suppressor in MSI-H cancers that regulates MDM4 splicing and reveals its role in oncogenic pathways.

Profile of the somatic mutational landscape in breast tumors from Hispanic/Latina women

This study analyzes the somatic mutational landscape of breast tumors in Hispanic/Latina women using whole-exome and RNA-seq, identifying common mutations and novel mutation signatures.

The CIC-ERF co-deletion underlies fusion independent activation of ETS family member, ETV1, to drive prostate cancer progression

This study identifies that the co-deletion of CIC and ERF leads to ETV1 activation, driving prostate cancer progression without fusion events.

Single-cell analysis of hepatoblastoma identifies distinct tumor cell signatures that predict susceptibility to chemotherapy using patient-specific tumor spheroids

This study identifies five distinct tumor cell subtypes in hepatoblastoma using single-cell analysis and shows that patient-derived spheroids can predict chemotherapy response based on transcriptomic signatures.

Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states

This study uses single-cell RNA-sequencing to analyze prostate cancer tumor microenvironment, identifying heterogeneous epithelial cell states and tumor-associated club cells.