Author

P. Allegakoen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

F. W. Huang· 2 shared H. N. W. Weinstein· 2 shared H. Song· 2 shared A. K. Shalek· 1 shared A. O. Giacomelli· 1 shared B. Gini· 1 shared B. Wang· 1 shared C. Gomez· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

F. W. Huang

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Author profile →

3 papers

Recent·Most cited

CDK4 or CDK6 upregulation induces DNA replication stress and genomic instability to cause EGFR targeted therapy resistance in lung cancer

B. Gini, P. Gui, W. Wu, D. L. Kerr, L. Tan, D. Barbosa, V. Olivas, P. Allegakoen, C. Gomez, P. Halliday, S. Elmes, V. Steri, T. Chakrabarti, T. G. Bivona, C. M. Blakely

This study shows that CDK4/6 upregulation causes DNA replication stress and genomic instability, leading to resistance to EGFR inhibitors in lung cancer, and suggests combining CDK4/6 and EGFR inhibitors as a treatment.

bioRxiv · Mar 12, 2024 · PreprintCancer Biology

RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4

H. N. W. Weinstein, K. Hu, L. Fish, Y.-A. Chen, P. Allegakoen, K. S. F. Hui, J. H. Pham, M. B. Baco, H. Song, A. O. Giacomelli, F. Vazquez, M. Ghandi, H. Goodarzi, F. W. Huang

This study identifies RPL22 as a tumor suppressor in MSI-H cancers that regulates MDM4 splicing and reveals its role in oncogenic pathways.

bioRxiv · Dec 10, 2023Cancer Biology

Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states

H. Song, H. N. W. Weinstein, P. Allegakoen, M. H. Wadsworth, J. Xie, H. Yang, F. Y. Feng, P. R. Carroll, B. Wang, M. R. Cooperberg, A. K. Shalek, F. W. Huang

This study uses single-cell RNA-sequencing to analyze prostate cancer tumor microenvironment, identifying heterogeneous epithelial cell states and tumor-associated club cells.

bioRxiv · Nov 6, 2020Cancer Biology