Lipid droplets sequester cell death effectors and delay regulated cell death execution
Yingquan Shan, Kinga B. Stopa, Akandé Rouchidane Eyitayo, Florence Jollivet, Victor Girard, Catherine Jamard, Lena Sapozhnikov, Eli Arama, Judit Szécsi, Mohammed Bendahmane, Nathalie Davoust, Ludivine Walter, Mingyao Liu, Nicolas Aznar, Gabriel Ichim, Bertrand Mollereau
The paper shows lipid droplets delay regulated cell death by sequestering mitochondrial effectors like Bax, thereby reducing apoptosis execution in cancer and germ cells.
bioRxiv · Jul 13, 2026 · PreprintCell Biology