M. S. Ladinsky

The genomic and cellular basis of biosynthetic innovation in rove beetles

This study investigates the genomic and cellular basis of biosynthetic innovation in rove beetles, identifying key genomic and cellular mechanisms underlying the evolution of defensive secretions.

Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation

The paper identifies a mutation in the SARS-CoV-2 nucleocapsid protein that enhances viral infection by promoting dimer formation and altering virion structure.

The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics

This study investigates the cellular effects of the PNPLA3-I148M variant, revealing its role in altering lipid droplet-Golgi dynamics and inducing proteomic and transcriptomic changes associated with liver disease.

An extracellular vesicle targeting ligand that binds to Arc proteins and facilitates Arc transport in vivo

The paper identifies Sas as an extracellular vesicle targeting ligand that binds to Arc proteins and enables their transport between cells in Drosophila.

Live imaging of SARS-CoV-2 infection in mice reveals neutralizing antibodies require Fc function for optimal efficacy

This study uses live imaging to show that neutralizing antibodies against SARS-CoV-2 need both Fab and Fc functions to effectively prevent and resolve infection in mice.

The evolution of interdependence in a four-way mealybug symbiosis

This paper studies the genomic and metabolic interdependence of two recently acquired gammaproteobacterial endosymbionts in mealybugs, showing their rapid adaptation to an intracellular lifestyle.

In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission

This study uses in vivo imaging to show that Siglec-1/CD169 on sentinel macrophages facilitates retrovirus transmission through multiple routes.

Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate

The paper uses fusion inhibitors to trap HIV-1 in a pre-hairpin intermediate state and visualizes it via electron tomography, revealing the structure of Env-mediated fusion.

Structure of the fission yeast actomyosin ring during constriction

This study uses cryo-electron tomography to image the 3D structure of the actomyosin ring in fission yeast during cell division, revealing the arrangement of actin filaments.

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

This study identifies LEM2 and CHMP7 as conserved factors that recruit ESCRT-III proteins to the nuclear envelope during closure in fission yeast and human cells.