G. A. O'Toole

How individual P. aeruginosa cells with diverse stator distributions collectively form a heterogeneous macroscopic swarming population

The paper shows that P. aeruginosa cells with different stator distributions create a heterogeneous swarming population through dynamic stator recruitment and motor intermittency.

Quantifying forms and functions of intestinal bile acid pools in mice

The paper quantifies ileal bile acid pools in mice and shows that Asbt-mediated transport dominates their size and composition, with loss of Asbt reducing pool size and altering transcriptional responses.

Persistent delay in maturation of the developing gut microbiota in infants with cystic fibrosis

This study identifies delayed gut microbiota maturation in infants with cystic fibrosis using longitudinal metagenomic data from CF and non-CF cohorts.

Bacterial mechanosensing of surface stiffness promotes signaling and growth leading to biofilm formation by Pseudomonas aeruginosa

This study shows that Pseudomonas aeruginosa responds to surface stiffness through mechanosensing, affecting signaling, growth, and biofilm formation.

Porous marine snow differentially benefits chemotactic, motile, and non-motile bacteria

This study shows that bacterial motility is essential for colonizing marine particles, while chemotaxis benefits at higher settling velocities, and non-motile bacteria disproportionately benefit from porous particle structures.

Non-motile subpopulations of Pseudomonas aeruginosa repress flagellar motility in motile cells through a type IV pili- and Pel-dependent mechanism

The paper shows non-motile Pseudomonas aeruginosa cells repress swarming motility in motile cells via type IV pili and Pel exopolysaccharide.

Biochemical and Structural Characterization of Two Cif-Like Epoxide Hydrolases from Burkholderia cenocepacia

This study characterizes two Cif-like epoxide hydrolases from Burkholderia cenocepacia, revealing their biochemical properties and structural differences.

Discovering the Molecular Determinants of Phaeobacter inhibens susceptibility to Phaeobacter phage MD18

This paper identifies Phaeobacter phage MD18, a novel phage infecting Phaeobacter inhibens, and finds that type IV pili serve as receptors for phage adsorption.

Phenotypic differences in reversible attachment behavior reveal distinct P. aeruginosa surface colonization strategies

The paper examines reversible attachment behavior in P. aeruginosa strains PAO1 and PA14, revealing distinct surface colonization strategies through single-cell tracking and stochastic modeling.

Modeling the control of bacterial infections via antibiotic-induced proviruses

This paper models how antibiotic treatment can control bacterial infections by inducing latent phage, showing that sub-inhibitory antibiotics can manage infections when bacteria carry latent viruses.