O. Brandman

Opi1-mediated transcriptional modulation orchestrates genotoxic stress response in budding yeast

This study shows Opi1 modulates transcription during genotoxic stress in budding yeast, affecting DNA damage response and metabolic pathways.

Diffusive lensing as a mechanism of intracellular transport and compartmentalization

This study uses agent-based simulations to show that heterogeneous diffusivity can lead to diffusive lensing, a nonequilibrium mechanism that affects particle movement and concentration in the cytoplasm.

Oxaliplatin kills cells via liquid-liquid demixing of nucleoli

This study shows oxaliplatin causes nucleolar liquid-liquid demixing, leading to cell death by disrupting nucleolar organization and transcription.

Quantitative analysis of the ubiquitin-proteasome system under proteolytic and folding stressors

The paper quantifies how proteolytic and folding stressors affect the ubiquitin-proteasome system in yeast, showing distinct adaptations in substrate degradation and Rpn4 regulation.

Protein products of non-stop mRNA disrupt nucleolar homeostasis

This study shows that nonstop mRNA proteins accumulate in nucleoli, disrupting their structure and function, and links this to neurodegeneration mechanisms.

Aggregation of CAT tails blocks their degradation and causes proteotoxicity in S. cerevisiae

This study shows that CAT tail aggregation in yeast causes proteotoxicity and blocks degradation of incomplete polypeptides.

Viscoadaptation controls intracellular reaction rates in response to heat and energy availability

This study shows budding yeast adjust intracellular viscosity via trehalose and glycogen to maintain reaction rates across temperature and energy changes.

Chaperone-Mediated Reflux of Secretory Proteins to the Cytosol During Endoplasmic Reticulum Stress

The paper identifies a chaperone-mediated process that refuxes properly folded ER proteins to the cytosol during ER stress, functioning parallel to ERAD.

MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure

The paper identifies MISTERMINATE as a mechanism linking mitochondrial dysfunction to proteostasis failure through translational termination impairment and C-terminal extension of mitochondrial proteins.

CAT tails drive on- and off-ribosome degradation of stalled polypeptides

The paper investigates how CAT tails enhance Ltn1-mediated degradation of stalled polypeptides and provide an alternative degradation pathway via Hul5.