Y. Kobayashi

Cell-cell adhesion drives patterning in stratified epithelia

The paper shows that cell-cell adhesion drives multicellular patterning in stratified epithelia through a mechanism called CAIP, influencing differentiation and proliferation.

A yeast two-hybrid system to obtain triple-helical ligands from combinatorial random peptide libraries

The paper describes a yeast two-hybrid system to select triple-helical peptides that bind to target proteins, demonstrating its effectiveness in identifying new binding sequences for PEDF.

Ikzf1 association with Foxp3 for Foxp3-dependent gene repression in Treg cells: induction of autoimmunity and tumor immunity by disrupting the association

This study shows that Ikzf1 associates with Foxp3 to repress genes in Treg cells, and disrupting this association leads to autoimmunity and enhanced tumor immunity.

Plant-mycorrhizal associations may explain the latitudinal gradient of plant community assembly

This study links latitudinal plant community assembly patterns to mycorrhizal type prevalence, showing that ectomycorrhizal trees drive spatial clustering in understory communities.

Allergic Asthma Responses Are Dependent on Macrophage Ontogeny

This study shows that altering macrophage ontogeny after homeostasis affects allergic airway responses to house dust mites.

Murine breast cancers disorganize the liver transcriptome in zonated manners

This study uses spatial transcriptomics to show that breast cancers disrupt liver zonation patterns, affecting specific metabolic and immune pathways in a zonated manner.

A chromosomal inversion may facilitate adaptation despite periodic gene flow in a freshwater fish

The paper identifies a chromosomal inversion in walleye fish that may promote adaptive divergence despite gene flow between lakes.

Pharmacologic rescue of circadian β-cell failure through P2Y1 purinergic receptor identified by small-molecule screen

The paper identifies the P2Y1 purinergic receptor as a target to rescue circadian β-cell failure using a small-molecule screen and validates ivermectin as a glucose-dependent secretagogue.

Phosphate starvation response precedes abscisic acid response under progressive mild drought in plants

The paper shows that phosphate starvation response precedes abscisic acid response in plants under mild drought, using field and controlled experiments.

Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

The paper shows that ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells, contributing to maladaptive renal repair after severe injury.

Asymbiotic mass production of the arbuscular mycorrhizal fungus Rhizophagus clarus

This study shows that combining strigolactone and methyl jasmonate with myristate and organic nitrogen in asymbiotic cultures of Rhizophagus clarus HR1 increases spore production and infectivity, supporting plant growth.

Revisiting the gastrin-releasing peptide/bombesin system: A reverse-evolutionary study considering Xenopus

This study investigates the evolutionary relationships of the gastrin-releasing peptide (GRP) and bombesin systems in vertebrates using Xenopus tropicalis, showing GRP is not a mammalian counterpart of bombesin and that the NMB/bombesin system has diversified in frogs.

Hair follicle stem cell progeny heal blisters while pausing skin development

The paper shows that skin blisters heal by sacrificing developmental programs, with HF stem cell progeny repairing wounds without promoting hair follicle growth.

A Versatile Oblique Plane Microscope for Large-Scale and High-Resolution Imaging of Subcellular Dynamics.

This paper introduces an improved oblique plane microscope with enhanced resolution and usability, demonstrating its application in imaging various subcellular dynamics and challenging biological phenomena.

Persistence of a novel regeneration-associated transitional cell state in pulmonary fibrosis

The paper identifies a novel transitional cell state in lung regeneration that exhibits senescence-like features and is enriched in fibrotic lung tissues, suggesting its role in pulmonary fibrosis pathogenesis.

Yolk-Sac-Derived Macrophages Progressively Expand in the Mouse Kidney with Age

This study shows that yolk-sac-derived macrophages increase with age in the mouse kidney, becoming a major population in older mice.