Author

D. Fachinetti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:chromatin & epigenetic regulation· 4 Research Focus:cell signaling & trafficking· 3 Assay:ChIP-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:development & morphogenesis· 2 Assay:DNA methylation· 2

Frequent Co-Authors

M. Dumont· 3 shared S. Hoffmann· 2 shared A. Aslanian· 1 shared A. Coulon· 1 shared A. E. Tijhuis· 1 shared A. Gatto· 1 shared A. Scelfo· 1 shared A. Smogorzewska· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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3 shared papersCell Biology

M. Dumont

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Author profile →

6 papers

Recent·Most cited

Short-term molecular consequences of chromosome mis-segregation for genome stability

L. Garribba, G. De Feudis, V. Martis, M. Galli, M. Dumont, Y. Eliezer, R. Wardenaar, M. R. Ippolito, D. R. Iyer, A. E. Tijhuis, D. C. Spierings, M. Schubert, S. Taglietti, C. Soriani, S. Gemble, , S. Santaguida

This study shows that aneuploidy can trigger chromosome instability (CIN) by causing DNA replication stress and continuous CIN, leading to genetically diverse cells with varying proliferation abilities.

bioRxiv · Jun 19, 2022Cell Biology

Live-cell micromanipulation of a genomic locus reveals interphase chromatin mechanics

V. I. P. Keizer, S. Grosse-Holz, M. Woringer, L. Zambon, K. Aizel, M. Bongaerts, L. Kolar-Znika, V. F. Scolari, S. Hoffmann, E. J. Banigan, L. A. Mirny, M. Dahan, D. Fachinetti, A. Coulon

The paper uses magnetic forces to manipulate a genomic locus in live human cells, revealing chromatin's viscoelastic properties and challenging the gel-like model.

bioRxiv · Apr 20, 2021Biophysics

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

S. Giunta, S. Herve, R. R. White, T. Wilhelm, M. Dumont, A. Scelfo, R. Gamba, C. K. Wong, G. Rancati, A. Smogorzewska, H. Funabiki, D. Fachinetti

This study shows that CENP-A chromatin prevents replication stress at centromeres, reducing structural aneuploidy by safeguarding DNA replication of alpha-satellite repeats.

bioRxiv · Sep 1, 2020Cell Biology

CENP-A overexpression drives distinct cell fates depending on p53 status

D. C. B. Jeffery, K. Podsypanina, A. Gatto, R. Ponce Landete, L. Bonneville, M. Dumont, D. Fachinetti, G. Almouzni

This study shows that CENP-A overexpression leads to different cell outcomes based on p53 status, promoting senescence with functional p53 or EMT without it.

bioRxiv · Jul 21, 2020Cancer Biology

DNA replication-mediated error correction of ectopic CENP-A deposition maintains centromere identity

Y. Nechemia-Arbely, K. H. Miga, O. Shoshani, A. Aslanian, M. A. McMahon, A. Y. Lee, D. Fachinetti, J. R. Yates, B. Ren, D. Cleveland

The paper shows DNA replication removes CENP-A from chromosome arms, preserving centromere identity by maintaining CENP-A at centromeres.

bioRxiv · Sep 27, 2018Cell Biology

Real Time de novo Deposition of Centromeric Histone-associated Proteins Using the Auxin Inducible Degradation System

S. Hoffmann, D. Fachinetti

The paper develops a method to study protein dynamics using auxin-inducible degradation, demonstrating real-time CENP-C deposition at centromeres.

bioRxiv · Apr 19, 2018Cell Biology