Author

G. Shui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Physiology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Organism:C. elegans· 3 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 3 Organism:human· 3 Assay:metabolomics· 3 Organism:mouse· 3

Frequent Co-Authors

S. M. Lam· 4 shared C. Zhang· 2 shared J. Wang· 2 shared W. Wang· 2 shared Y. Ma· 2 shared A. Yavuz· 1 shared B. Zhang· 1 shared B.-H. Kang· 1 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersCell Biology

S. M. Lam

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

J. Wang, Z. An, Z. Wu, W. Zhou, P. Sun, P. Wu, R. Xue, S. Dang, X. Bai, W. Wang, R. Chen, Y. Du, P. Huang, S. M. Lam, Y. Ai, , K. He

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

bioRxiv · Jul 5, 2024Cell Biology

Lithocholic acid phenocopies rejuvenating and life-extending effects of calorie restriction

Q. Qu, Y. Chen, Y. Wang, S. Long, W. Wang, H.-Y. Yang, M. Li, X. Tian, X. Wei, Y.-H. Liu, S. Xu, C. Zhang, M. Zhu, S. M. Lam, J. Wu, , S.-C. Lin

This study identifies lithocholic acid as a metabolite that mimics calorie restriction's anti-aging effects in multiple species through AMPK activation.

bioRxiv · Dec 7, 2023 · PreprintPhysiology

Target lipidomics reveals associations between serum sphingolipids and insulin sensitivity by the glucose clamp

J. Ye, X. Ye, W. Jiang, C. Lu, X. Geng, C. Zhao, Y. Ma, P. Yang, S. M. Lam, G. Shui, T. Yang, J. Z. Li, Y. Gong, Z. Fu, H. Zhou

This study identifies serum sphingolipids associated with insulin sensitivity using lipidomics and glucose clamp techniques, finding SM/Cer and SM d18:0/26:0 as potential biomarkers.

bioRxiv · Oct 23, 2020Physiology

BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor

C. Zhang, C. Hao, G. Shui, W. Li

This study identifies BLOS1 as a mediator of kinesin switch during LDLR endosomal recycling, showing its role in RE transport and LDL clearance.

bioRxiv · Apr 22, 2020Cell Biology

Reconstruction and dynamics of human intestinal microbiome observed in situ

X. Liu, M. Dai, Y. Ma, N. Zhao, H. Zhang, L. Xiang, H. Tian, G. Shui, F. Zhang, J. Wang

This study samples ileocecal microbiome in situ using transendoscopic tubing and finds distinct metatranscriptomes compared to fecal samples, diurnal rhythms in bacterial activity, and metabolomic parallels to gut microbiome changes.

bioRxiv · Feb 25, 2020Microbiology

Neuronal lipolysis participates in PUFA-mediated neural function and neurodegeneration

L. Yang, J. Liang, S. M. Lam, A. Yavuz, M. C. Wang, G. Shui, M. Ding, X. Huang

This study shows that neuronal lipolysis prevents lipid droplet accumulation and alleviates neurodegeneration in C. elegans by regulating PUFA partitioning and phospholipid incorporation.

bioRxiv · Feb 13, 2020Cell Biology

Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain

Z. Cao, Y. Hao, Y. Y. Lee, P. Wang, X. Li, K. Xie, W. J. Lam, Y. Qiu, G. Shui, P. Liu, J. Qu, B.-H. Kang, H. Y. Mak

The paper shows dietary fatty acids influence lipid droplet diversity via SEIP-1 enrichment in an ER subdomain in C. elegans and mammalian cells.

bioRxiv · Sep 22, 2018Cell Biology