K. Xie

Whole-genome resequencing revealed the Origin and Domestication of Chinese Domestic Rabbits

This study uses whole-genome resequencing to trace the origin and domestication of Chinese domestic rabbits, identifying genetic adaptations and multiple potential origins.

Identification and classification of the genomes of novel Microviruses in a poultry slaughterhouse

This study identifies 98 novel microvirus genomes from a poultry slaughterhouse, classifies them into 6 new subfamilies and 3 higher-level units, and expands their known host range.

Mutation of OsCDS5 confers broad-spectrum disease resistance in rice

This study shows that mutating OsCDS5 in rice enhances resistance to multiple diseases by increasing ROS production and defense gene expression.

TESOGENASE, An Engineered Nuclease Editor for Enhanced Targeted Genome Integration

The paper introduces enGager, a system that enhances ssDNA-mediated genome integration by fusing Cas9 with ssDNA-binding proteins, achieving up to 6-fold efficiency improvements for large transgene knock-in.

Circular single-stranded DNA is a superior homology-directed repair donor template for efficient genome engineering

This paper develops a non-viral system for efficient genome engineering using circular single-stranded DNA (cssDNA) donors, achieving high knock-in efficiency and improved safety compared to viral vectors.

Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process in C57BL/6J Mice

This study uses large-scale phenotyping in mice to show that longevity regulators affect age-sensitive phenotypes before detectable aging begins, rather than slowing aging rates.

ssc-micorRNA-132 suppresses the Clostridium perfringens beta2 toxin induced inflammation and apoptosis of IPEC-J2 cells via targeting DACH1

This study shows that ssc-miR-132 reduces inflammation and apoptosis in IPEC-J2 cells caused by C. perfringens beta2 toxin by targeting DACH1.

Dietary S. maltophilia promotes fat storage by enhancing lipogenesis and ER-LD contacts in C. elegans

Identification of Functional Noncoding RNA-encoded Proteins on Lipid Droplets

The paper identifies noncoding RNA-encoded proteins on lipid droplets, discovering LDANP1 which modulates lipid metabolism and insulin sensitivity.

Metabolomic markers of colorectal tumor with different clinicopathological features

The paper identifies metabolic subtypes of colorectal cancer using metabolomics and finds correlations between these subtypes and clinical outcomes.

Ultrafast immunostaining of organ-scale tissues for scalable proteomic phenotyping

The paper introduces eFLASH, a method for rapid, uniform labeling of organ-scale tissues, enabling scalable proteomic phenotyping across species and tissues.

Scalable image processing techniques for quantitative analysis of volumetric biological images from light-sheet microscopy

The paper presents a scalable image processing pipeline for analyzing large volumetric light-sheet microscopy images of mouse brains, improving speed and providing alignment and segmentation tools.

Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain

The paper shows dietary fatty acids influence lipid droplet diversity via SEIP-1 enrichment in an ER subdomain in C. elegans and mammalian cells.