Author

G. Skariah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

L. Li· 3 shared J. A. Carozza· 2 shared A. F. Cordova· 1 shared A. J. Joseph· 1 shared E. E. Graves· 1 shared F. B. Yu· 1 shared H. Goodarzi· 1 shared J. A. Brown· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCancer Biology

L. Li

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway

S. Wang, V. Bohnert, A. J. Joseph, V. Sudaryo, J. Swinderman, F. B. Yu, X. Lyu, G. Skariah, V. Subramanyam, L. A. Gilbert, H. Goodarzi, L. Li

This study identifies ENPP1 as an innate immune checkpoint that suppresses the cGAMP-STING pathway, promoting tumor growth and metastasis, and shows that inhibiting its cGAMP hydrolase activity enhances cancer immunity.

bioRxiv · Jun 1, 2023 · PreprintCancer Biology

Probing pathophysiology of extracellular cGAMP with substrate-selective ENPP1

J. A. Carozza, A. F. Cordova, Y. AlSaif, V. Böhnert, G. Skariah, L. Li

This paper identifies a mutation in ENPP1 that selectively inhibits cGAMP degradation, enabling study of extracellular cGAMP's role in antiviral immunity and disease.

bioRxiv · May 4, 2021 · PreprintImmunology

Extracellular 2’3’-cGAMP is an immunotransmitter produced by cancer cells and regulated by ENPP1

J. A. Carozza, V. Boehnert, K. C. Nguyen, G. Skariah, K. E. Shaw, J. A. Brown, M. Rafat, R. von Eyben, E. E. Graves, J. S. Glenn, M. Smith, L. Li

The paper identifies extracellular 2’3’-cGAMP as an immunotransmitter released by cancer cells, regulated by ENPP1, and shows its therapeutic potential in tumor treatment.

bioRxiv · Oct 7, 2019Biochemistry