Author

J. A. Carozza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

L. Li· 5 shared V. Böhnert· 3 shared G. Skariah· 2 shared J. A. Brown· 2 shared L. J. Lahey· 2 shared M. Smith· 2 shared R. E. Mardjuki· 2 shared V. Boehnert· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersBiochemistry

L. Li

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A cGAMP-containing hydrogel for prolonged SARS-CoV-2 RBD subunit vaccine exposure induces a broad and potent humoral response

V. Böhnert, E. C. Gale, L. J. Lahey, J. Yan, A. E. Powell, B. S. Ou, J. A. Carozza, L. Li, E. Appel

A cGAMP-containing hydrogel vaccine enhances RBD subunit vaccine efficacy by enabling sustained antigen and adjuvant delivery, resulting in broader and more potent antibody responses.

bioRxiv · Jul 3, 2021 · PreprintBioengineering

Probing pathophysiology of extracellular cGAMP with substrate-selective ENPP1

J. A. Carozza, A. F. Cordova, Y. AlSaif, V. Böhnert, G. Skariah, L. Li

This paper identifies a mutation in ENPP1 that selectively inhibits cGAMP degradation, enabling study of extracellular cGAMP's role in antiviral immunity and disease.

bioRxiv · May 4, 2021 · PreprintImmunology

Structure-aided development of small molecule inhibitors of ENPP1, the extracellular phosphodiesterase of the immunotransmitter cGAMP

J. A. Carozza, J. A. Brown, V. Boehnert, D. Fernandez, Y. AlSaif, R. E. Mardjuki, M. Smith, L. Li

This study develops small molecule ENPP1 inhibitors with sub-nanomolar potency and demonstrates their efficacy in delaying tumor growth in a breast cancer model.

bioRxiv · May 30, 2020Biochemistry

The LRRC8A:C Heteromeric Channel Is a cGAMP Transporter and the Dominant cGAMP Importer in Human Vasculature Cells

L. J. Lahey, X. Wen, R. E. Mardjuki, V. Böhnert, G. T. Hess, C. Ritchie, J. A. Carozza, M. Maduke, M. C. Bassik, L. Li

The paper identifies LRRC8A:C as a cGAMP transporter in human vasculature cells and shows it mediates cGAMP import/export and is the dominant importer in these cells.

bioRxiv · Feb 13, 2020 · PreprintBiochemistry

Extracellular 2’3’-cGAMP is an immunotransmitter produced by cancer cells and regulated by ENPP1

J. A. Carozza, V. Boehnert, K. C. Nguyen, G. Skariah, K. E. Shaw, J. A. Brown, M. Rafat, R. von Eyben, E. E. Graves, J. S. Glenn, M. Smith, L. Li

The paper identifies extracellular 2’3’-cGAMP as an immunotransmitter released by cancer cells, regulated by ENPP1, and shows its therapeutic potential in tumor treatment.

bioRxiv · Oct 7, 2019Biochemistry