Author

J. S. Glenn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 4 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

R. S. Baric· 3 shared C. E. Edwards· 2 shared E. A. Pham· 2 shared K. Nguyen· 2 shared R. Das· 2 shared R. J. Hagey· 2 shared T. P. Sheahan· 2 shared W. Kladwang· 2 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCell Biology

R. S. Baric

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Identification and targeting of a pan-genotypic influenza A virus RNA structure that mediates packaging and disease.

R. J. Hagey, M. Elazar, S. Tian, E. A. Pham, W. Kladwang, L. Ben-Avi, K. Nguyen, A. Xiong, M. Rabinovich, S. Schaffert, T. Avisar, B. Fram, P. Liu, P. Khatri, J. K. Taubenberger, , J. S. Glenn

This paper identifies a conserved RNA structure in influenza A virus that mediates packaging and disease, showing that targeting it inhibits virus production and reduces disease severity.

bioRxiv · Aug 21, 2021 · PreprintMicrobiology

Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures

A. A. Salahudeen, S. S. Choi, A. Rustagi, J. Zhu, S. M. de la O, R. A. Flynn, M. Margalef-Catala, A. J. M. Santos, J. Ju, A. Batish, V. van Unen, T. Usui, G. X. Y. Zheng, C. E. Edwards, L. E. Wagar, , C. J. Kuo

This paper develops a feeder-free organoid culture system for human distal lung progenitors and demonstrates SARS-CoV-2 infection of club cells in a novel in vitro model.

bioRxiv · Jul 27, 2020 · PreprintCell Biology

Cryo-electron Microscopy and Exploratory Antisense Targeting of the 28-kDa Frameshift Stimulation Element from the SARS-CoV-2 RNA Genome

K. Zhang, I. N. Zheludev, R. J. Hagey, M. T.-P. Wu, R. Haslecker, Y. J. Hou, R. Kretsch, G. D. Pintilie, R. Rangan, W. Kladwang, S. Li, E. A. Pham, C. Bernardin, R. S. Baric, T. P. Sheahan, , R. Das

The paper uses cryo-EM and ASO experiments to study the SARS-CoV-2 FSE structure and its potential as an antiviral target, finding a complex tertiary structure but challenges in effective inactivation.

bioRxiv · Jul 18, 2020Biochemistry

A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasures

K. H. Dinnon, S. R. Leist, A. Schafer, C. E. Edwards, D. R. Martinez, S. A. Montgomery, A. West, B. L. Yount, Y. J. Hou, L. E. Adams, K. L. Gully, A. J. Brown, E. Huang, M. D. Bryant, I. C. Choong, , R. S. Baric

This paper develops a mouse-adapted SARS-CoV-2 model to evaluate medical countermeasures, showing age-related disease severity and the efficacy of IFN lambda-1a.

bioRxiv · May 6, 2020Microbiology

Extracellular 2’3’-cGAMP is an immunotransmitter produced by cancer cells and regulated by ENPP1

J. A. Carozza, V. Boehnert, K. C. Nguyen, G. Skariah, K. E. Shaw, J. A. Brown, M. Rafat, R. von Eyben, E. E. Graves, J. S. Glenn, M. Smith, L. Li

The paper identifies extracellular 2’3’-cGAMP as an immunotransmitter released by cancer cells, regulated by ENPP1, and shows its therapeutic potential in tumor treatment.

bioRxiv · Oct 7, 2019Biochemistry