M. K. Lee

Deletion of Glyoxalase 1 exacerbates acetaminophen-induced hepatotoxicity in mice

This study shows that deleting Glyoxalase 1 worsens acetaminophen-induced liver damage in mice by increasing oxidative stress and necrosis.

Alteration of DNMT1/DNMT3A by eribulin elicits global DNA methylationchanges with potential therapeutic implications for triple-negative breastcancer

This study shows eribulin treatment alters DNA methylation and epigenetic modifier expression in TNBC cells, suggesting potential therapeutic use in triple-negative breast cancer.

An immune cell lipid atlas reveals the basis of susceptibility to ferroptosis

The paper characterizes immune cell lipidomes and shows how lipid composition influences susceptibility to ferroptosis.

Lineage plasticity enables low-ER luminal tumors to evolve and gain basal-like traits

The paper shows low-ER luminal breast tumors can evolve into basal-like traits through lineage plasticity, with SOX10 identified as a potential driver.

ROCK1 regulates insulin secretion from β-cells

This study shows that ROCK1 is essential for glucose-stimulated insulin secretion in β-cells and regulates pyruvate kinase signaling.

Antiviral activity of lambda-carrageenan against influenza viruses in mice and severe acute respiratory syndrome coronavirus 2 in vitro

This study evaluates lambda-carrageenan's antiviral effects against influenza and SARS-CoV-2, showing dose-dependent inhibition and protective effects in mice.

Generation of tonsil organoids as an ex vivo model for SARS-CoV-2 infection

This study established tonsil epithelial cell-derived organoids and demonstrated their feasibility as an ex vivo model for SARS-CoV-2 infection.

Spatial organization and dynamics of RNase E and ribosomes in Caulobacter crescentus

This study uses microscopy to show RNase E and ribosomes are spatially organized in Caulobacter crescentus, with clustering linked to RNA availability and rRNA gene location.