H. Rao

Epithelial NSD2 maintains FMOs-mediated taurine biosynthesis to prevent intestinal barrier disruption

The paper shows NSD2 maintains taurine biosynthesis via FMOs in intestinal epithelial cells, preventing barrier disruption in IBD.

Multilevel regulation of NF-kappa B signaling by NSD2 suppresses Kras-driven pancreatic tumorigenesis

This study shows NSD2 acts as a tumor suppressor in Kras-driven pancreatic cancer by regulating NF-kappa B signaling through multiple mechanisms.

Host network-based discovery of critical regulators of innate immunity, virus growth, and pathogenesis in influenza virus infection

The paper identifies novel innate immune regulators affecting influenza virus replication and pathogenesis through experimental validation of network model predictions.

The Histone Methyltransferase SETD2 Modulates Oxidative Stress to Attenuate Colonic Inflammation and Tumorigenesis in Mice

This study shows that SETD2 deficiency in mice worsens colonic inflammation and tumorigenesis by increasing oxidative stress and impairing epithelial barrier function.

SETD2 deficiency impairs β-catenin destruction complex to facilitate renal cell carcinoma formation

This study shows that SETD2 deficiency disrupts the β-catenin destruction complex, promoting ccRCC formation, and links SETD2-mediated H3K36me3 to Wnt/β-catenin signaling in renal cancer.

Di-Ras2 Promotes Renal Cell Carcinoma Formation by Activating the MAPK Pathway in the Absence of VHL

This study identifies Di-Ras2 as an oncogene in ccRCC that promotes tumor formation by activating the MAPK pathway in the absence of VHL.