Y. Tamura

Molecular dynamics unveils multiple-site binding of inhibitors with reduced activity on the surface of dihydrofolate reductase

This study uses molecular dynamics to analyze inhibitor binding to DHFR, showing that reduced activity correlates with multiple-bound states on the protein surface.

Suppressive effects of oroxylin A on intracellular proliferation of Toxoplasma gondii via host cell ERK phosphorylation inhibition

This study shows oroxylin A inhibits Toxoplasma gondii intracellular growth by blocking host cell ERK phosphorylation, similar to MEK1 inhibitors.

Label-free imaging of intracellular structures in living mammalian cells via external apodization phase-contrast microscopy

This study introduces ExAPC microscopy for label-free visualization of intracellular structures, showing its ability to resolve biomolecular condensates, lipid droplets, and mitochondria with high spatiotemporal resolution.

qMaLioffG: A single green fluorescent protein FLIM indicator enabling quantitative imaging of endogenous ATP

The paper introduces qMaLioffG, a green fluorescent protein FLIM indicator that quantitatively measures endogenous ATP levels by detecting fluorescence lifetime changes in physiological ATP concentrations.

Visualization of lake succession as indicated by macrophyte species composition and trophic levels in lakes subdivided by volcanic eruption at Akan Caldera, Hokkaido, Japan

The paper uses lake size and watershed area ratios to predict trophic levels and macrophyte composition in lakes formed by volcanic eruptions, revealing a pattern of hydrarch succession.

A non-canonical unfolded protein response pathway and mitochondrial dynamics control the number of ER-mitochondria contact sites

This study identifies a novel role of mitochondrial dynamics in regulating ER-mitochondria contact sites in yeast, showing that ER stress affects ERMES cluster stability independently of the canonical UPR pathway.

Analysis host-recognition mechanism of staphylococcal kayvirus phiSA039 reveals a novel strategy that protects Staphylococcus aureus against infection by Staphylococcus pseudintermedius Siphoviridae phages

This study identifies a novel host-recognition mechanism in the kayvirus phiSA039 that allows it to infect both Staphylococcus aureus and S. pseudintermedius by adapting its receptor and exploiting differences in WTA glycosylation.

Visualizing multiple inter-organelle contact sites using the organelle-targeted split-GFP system

The paper evaluates the split-GFP system for visualizing inter-organelle contact sites in yeast and mammalian cells, showing its utility and limitations.