T. Sakamoto

Development of the 12-base short dimeric myogenetic oligodeoxynucleotide that induces myogenic differentiation

This paper develops a 12-base myogenetic oligodeoxynucleotide that maintains the myogenic activity of a longer sequence while improving drug efficacy and synthesis cost.

Comparative analyses of adsorbed circulating proteins in the PMMA and PES hemodiafilters in patients on predilution online hemodiafiltration

This study compares protein adsorption by PMMA and PES hemodiafilters in OL-HDF, finding PMMA adsorbs more inflammatory proteins like IL-6 and beta-2 microglobulin.

Non-contact respiratory measurements of outdoor-housed rhesus macaques (Macaca mulatta) using millimeter-wave radars

This paper validates the use of millimeter-wave radar to measure respiration in outdoor-housed rhesus macaques from a distance of >5 meters.

Phylogenetic Analysis of the rfb Locus Genes of the Genus Leptospira of Serogroups Serjoe, Mini and Hebdomadis

The paper uses phylogenetic analysis of rfb locus genes from Leptospira serogroups to study evolutionary dynamics and lateral gene transfer events.

The evolution of RNA interference among Metazoa

This study investigates the evolution of RNA interference mechanisms in Metazoa, finding that the endo-siRNA pathway is lost in Lophotrochozoa while miRNAs remain conserved.

MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states.

This study identifies MBNL1 as a regulator of cardiac cell state transitions, showing it controls RNA stability to switch between regenerative and differentiated states.

Charge neutralization and β-elimination cleavage mechanism of family 42 L-rhamnose-α-1,4-D-glucuronate lyase revealed using neutron crystallography

This paper uses neutron crystallography to reveal the charge neutralization and β-elimination mechanism of FoRham1, an enzyme that cleaves gum arabic.

Sunscreen redox status in a multicellular cyanobacterium visualized by Raman scattering spectral microscope

The paper uses Raman scattering spectral microscopy to visualize the 3D subcellular distribution and redox status of scytonemin in a cyanobacterium under different physiological conditions.

Chromosome-level genome assembly of Rorippa aquatica revealed its allotetraploid origin and mechanisms of heterophylly upon submergence

This study assembled the chromosome-level genome of Rorippa aquatica to investigate its allotetraploid origin and the molecular mechanisms of heterophylly under submergence.

Collaborative workflow between pathologists and deep learning for evaluation of tumor cellularity in lung adenocarcinoma

This paper develops an AI model for tumor cellularity evaluation in lung adenocarcinoma, validated through collaboration with pathologists to improve accuracy.

Auxin-driven ecophysiological diversification of leaves in domesticated tomato

The paper identifies a single-nucleotide polymorphism in an auxin-related transcription factor that controls the distribution of heterobaric and homobaric leaves in tomatoes.

Deceleration of cell cycle underpins a switch from proliferative- to terminal division in plant stomatal lineage

The paper identifies SMR4 as a cyclin-dependent kinase inhibitor that decelerates the cell cycle during the transition from asymmetric to symmetric divisions in plant stomatal lineage.

Binding mechanism underlying FIH-1 suppression caused by the N-terminal disordered region of Mint3

This study investigates the binding mechanism between Mint3 and FIH-1, identifying a novel core site and thermodynamic contributions of Mint3's disordered region.

Establishment of a new sex-determining allele driven by sexually antagonistic selection

The paper models the turnover of sex-determining loci under sexually antagonistic selection, showing how different selection modes affect turnover rates and polymorphism patterns.

Revisiting the gastrin-releasing peptide/bombesin system: A reverse-evolutionary study considering Xenopus

This study investigates the evolutionary relationships of the gastrin-releasing peptide (GRP) and bombesin systems in vertebrates using Xenopus tropicalis, showing GRP is not a mammalian counterpart of bombesin and that the NMB/bombesin system has diversified in frogs.

Establishment Process of a Magic Trait Allele subject to Both Divergent Selection and Assortative Mating

The paper analyzes the establishment of a magic trait allele under divergent selection and assortative mating, showing how these forces interact to determine allele fate.

Synergic Interaction between Permethrin and Bt toxins discovered using RNA-seq

The paper identifies permethrin and Bt toxin as a novel negatively correlated cross-resistance pair in insects through transcriptomic analysis and in vivo testing.

Theoretical Expression for the Evolution of Genomic Island of Speciation: From Its Birth to Preservation

This study develops theoretical models to describe the evolution of genomic islands of speciation, focusing on their formation and preservation under gene flow.

Changes choroidal area following trabeculectomy: long-term effect of intraocular pressure reduction

This study examines how intraocular pressure reduction after trabeculectomy affects choroidal areas, finding increased macular and peripapillary choroidal areas with significant interstitial area expansion.