Y. Nagai

Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice

Reconstitution of C9orf72 (GGGGCC) repeat-associated non-AUG translation with purified components.

This study reconstitutes G4C2 repeat-associated non-AUG translation using purified human factors and identifies key features of the process.

Conformational switch in the alpha-synuclein C-terminus domain directs its fibril polymorphs

This study identifies a conformational switch in the alpha-synuclein C-terminus domain that determines fibril polymorphs by altering morphology in response to ionic strength and temperature.

Focal adhesion membrane is dotted with protein islands and partitioned for molecular hop diffusion

The paper demonstrates that focal adhesion membrane is partitioned into compartments where molecules undergo hop diffusion, with protein islands acting as dynamic hubs for integrin interactions.

Development of ultrafast camera-based imaging of single fluorescent molecules and live-cell PALM

This paper develops an ultrafast camera system for single fluorescent-molecule imaging and live-cell PALM, achieving high temporal and spatial resolution for studying cellular dynamics.

MeDUsA: A novel system for automated axon quantification to evaluate neuroaxonal degeneration

MeDUsA automates axon quantification in Drosophila to assess neuroaxonal degeneration, showing axonal degeneration occurs with ND-related proteins but not correlated with REP.

Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model

This paper identifies a small molecule that targets toxic RNA repeats in a Drosophila model of SCA31, reducing RNA foci and alleviating disease symptoms.

Chloroplast acquisition without the gene transfer in kleptoplastic sea slugs, Plakobranchus ocellatus

This study sequenced the genome of a kleptoplastic sea slug and found no evidence of algal gene transfer to the nucleus, showing photosynthesis can occur without nuclear gene transfer.

An anti-amyloidogenic treatment to specifically block the consolidation of traumatic events in mouse

This paper develops a transgenic mouse expressing QBP1 to block traumatic memory consolidation, showing impaired aversive memory and reduced amyloid oligomerization.