Author

D. B. Sattelle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 7 Zoology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:drug response / drug discovery· 5 Organism:mouse· 4 Organism:Arabidopsis· 2 Organism:C. elegans· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

F. A. Partridge· 7 shared A. J. Russell· 4 shared K. J. Else· 4 shared R. Forman· 4 shared A. E. Brown· 3 shared B. C. Poulton· 3 shared G. J. Lycett· 3 shared G. M. Wynne· 3 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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7 shared papersPharmacology & Toxicology

F. A. Partridge

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Aedes aegypti CCEae3A carboxylase expression confers carbamate, organophosphate and limited pyrethroid resistance in a model transgenic mosquito

B. C. Poulton, F. Colman, A. Anthousi, D. B. Sattelle, G. J. Lycett

This study shows that overexpression of CCEae3A in Anopheles gambiae mosquitoes confers resistance to organophosphates, carbamates, and limited pyrethroids, validating its role in insecticide resistance.

bioRxiv · Aug 16, 2023 · PreprintZoology

A drug repurposing screen for whipworms informed by comparative genomics

A. Coghlan, F. A. Partridge, M. A. Duque-Correa, G. Rinaldi, S. Clare, L. Seymour, C. Brandt, T. T. Mkandawire, C. McCarthy, N. Holroyd, M. Nick, A. E. Brown, S. Tonitiwong, D. B. Sattelle, M. Berriman

This paper identifies potential anti-whipworm drugs by testing approved human drugs ex vivo and in vivo, finding limited efficacy due to pharmacokinetic challenges.

bioRxiv · Mar 2, 2023Pharmacology & Toxicology

Screening the Medicines for Malaria Pandemic Response Box chemical library on Caenorhabditis elegans identifies re-profiled candidate anthelmintic drug leads

M. Nick, F. A. Partridge, R. Forman, C. J. R. Bataille, K. J. Else, A. J. Russell, D. B. Sattelle

The paper screens a chemical library on C. elegans to identify potential anthelmintic drug leads effective against parasitic nematodes.

bioRxiv · Aug 10, 2022 · PreprintPharmacology & Toxicology

Actions of camptothecin derivatives on larvae and adults of the arboviral vector Aedes aegypti

F. A. Partridge, B. C. Poulton, M. A. I. Lake, R. A. Lees, H.-J. Mann, G. J. Lycett, D. B. Sattelle

This study identifies camptothecin derivatives as effective against Aedes aegypti larvae and adults, with potential for dual targeting of mosquitoes and Zika virus.

bioRxiv · Sep 6, 2021Pharmacology & Toxicology

Automated phenotyping of mosquito larvae enables high-throughput screening for novel larvicides and offers potential for smartphone-based detection of larval insecticide resistance

S. D. Buckingham, F. A. Partridge, B. C. Poulton, B. S. Miller, R. A. McKendry, G. J. Lycett, D. B. Sattelle

The paper develops an automated phenotyping platform for mosquito larvae to enable high-throughput screening of larvicides and detect insecticide resistance.

PLOS Neglected Tropical Diseases · Jun 3, 2021Peer-reviewedPharmacology & Toxicology

Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites - Trichuris muris, Brugia malayi, Heligmosomoides polygyrus and Schistosoma mansoni

F. A. Partridge, C. J. Bataille, R. Forman, A. E. Marriott, J. Forde-Thomas, C. Häberli, R. L. Dinsdale, J. D. O'Sullivan, N. J. Willis, G. M. Wynne, H. Whiteland, J. Archer, A. Steven, J. D. Turner, J. Keiser, , D. B. Sattelle

The paper investigates the structure-activity relationship of dihydrobenzoxazepinone (DHB) compounds against various parasitic nematodes and trematodes, identifying key structural features for anthelmintic activity.

ACS Infectious Diseases · Apr 2, 2021Peer-reviewedPharmacology & Toxicology

2,4-Diaminothienopyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm

F. A. Partridge, R. Forman, N. J. Willis, C. J. Bataille, E. A. Murphy, A. E. Brown, N. Heyer-Chauhan, B. Marinic, D. J. Sowood, G. M. Wynne, K. J. Else, A. J. Russell, D. B. Sattelle

This paper identifies a new class of anthelmintic compounds, DATPs, effective against whipworm adult and egg stages, suggesting potential for environmental control strategies.

bioRxiv · Apr 26, 2018Pharmacology & Toxicology

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes

F. A. Partridge, A. E. Brown, S. D. Buckingham, N. J. Willis, G. M. Wynne, R. Forman, K. J. Else, A. A. Morrison, J. B. Matthews, A. J. Russell, D. A. Lomas, D. B. Sattelle

The paper develops an automated system for screening chemical libraries against nematodes, identifying known and novel anthelmintic compounds.

bioRxiv · Sep 11, 2017Pharmacology & Toxicology