Author

I. Castello-Serrano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

I. Levental· 4 shared K. R. Levental· 2 shared A. Donlic· 1 shared A. H. Tavares· 1 shared A. Ploss· 1 shared A. S. Holehouse· 1 shared B. D. Levy· 1 shared B. Diaz-Rohrer· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersCell Biology

I. Levental

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4 papers

Recent·Most cited

Partitioning to ordered membrane domains regulates the kinetics of secretory traffic

I. Castello-Serrano, F. A. Heberle, B. Diaz-Rohrer, R. Ippolito, C. R. Shurer, P. Lujan, F. Campelo, K. R. Levental, I. Levental

The paper investigates how membrane domains influence secretory traffic kinetics, finding that raft affinity affects Golgi exit rates but not ER exit.

bioRxiv · Apr 18, 2023Cell Biology

Coupling of protein condensates to ordered lipid domains determines functional membrane organization

H.-Y. Wang, S. H. Chan, S. Dey, I. Castello-Serrano, J. Ditlev, M. K. Rosen, K. R. Levental, I. Levental

This study shows that protein condensates and lipid domains couple to organize T-cell membrane function during activation.

bioRxiv · Aug 2, 2022Cell Biology

Membrane phase separation drives organization at B cell receptor clusters

S. A. Shelby, I. Castello-Serrano, K. Wisser, I. Levental, S. Veatch

The paper proposes a framework for lipid-driven plasma membrane heterogeneity in B cells, supported by observations of receptor phosphorylation in perturbed systems.

bioRxiv · May 12, 2021 · PreprintBiophysics

SARS-CoV-2 Requires Cholesterol for Viral Entry and Pathological Syncytia Formation

D. W. Sanders, C. C. Jumper, P. J. Ackerman, D. Bracha, A. Donlic, H. Kim, D. Kenney, I. Castello-Serrano, S. Suzuki, T. Tamura, A. H. Tavares, M. Saeed, A. S. Holehouse, A. Ploss, I. Levental, , C. P. Brangwynne

This study identifies cholesterol's essential role in SARS-CoV-2 membrane fusion and syncytia formation, suggesting statins may benefit COVID-19 patients.

bioRxiv · Dec 14, 2020Cell Biology