H. Yue

ROS Mediated the Photodynamic Antibacterial of Vibrio vulnificus by a DNA-Targeted Molecular Rotor Probe

This paper introduces a novel fluorescent probe, BDTP, that effectively kills Vibrio vulnificus through photodynamic antibacterial activity and promotes wound healing in an animal model.

Thymidine Phosphorylase Promotes the Formation of Abdominal Aortic Aneurysm in Mice Fed a Western Diet

This study shows that TYMP promotes abdominal aortic aneurysm (AAA) in mice fed a Western diet by enhancing inflammation, thrombosis, and MMP2 activation while inhibiting vascular smooth muscle cell function.

Thymidine Phosphorylase Mediates SARS-CoV-2 Spike Protein Enhanced Thrombosis in K18-hACE2TG Mice

This study identifies thymidine phosphorylase (TYMP) as a mediator of SARS-CoV-2 spike protein-induced thrombosis in mice, showing that TYMP inhibition reduces thrombosis and coagulation.

Degradation of indole-3-acetic acid by plant-associated microbes

This study identifies bacterial isolates capable of degrading indole-3-acetic acid (IAA) from Arabidopsis and rice roots, revealing their functional roles and association with IAA producers.

Camel milk affects serum metabolites by modulating the intestinal microflora

This study shows that camel milk modulates gut microbiota and serum metabolites in rats, with beneficial bacteria and metabolites resembling those of healthy individuals.

BMP signaling maintains auricular chondrocyte identity and prevents microtia development by inhibiting protein kinase A

This study shows BMP signaling maintains auricular chondrocyte identity and prevents microtia by inhibiting PKA, through a switch from chondrogenic to osteogenic programs.

African swine fever virus I196L is a virulence determinant and its deletant induces robust protection in Domestic pig

This paper deletes the I196L gene from ASFV SY18, resulting in a less virulent recombinant virus that protects pigs against ASFV challenge.

Ultrafast, one-step, and microwave heating-based synthesis of DNA/RNA-AuNP conjugates

This paper develops a microwave heating-based method to rapidly synthesize DNA/RNA-AuNP conjugates with high stability and broad applicability.

An ultrapotent neutralizing bispecific antibody with broad spectrum against SARS-CoV-2 variants

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

PI3K inhibition reverses migratory direction of single cells but not cell groups in electric field

The paper shows that PI3K inhibition reverses single cell migration direction in electric fields but not in large cell groups, with different behavior observed in group interiors and edges.

Mouse thy1-positive spermatogonia suppress the proliferation of spermatogonial stem cells by Extracellular vesicles in vitro

This study shows that extracellular vesicles from thy1-positive spermatogonia suppress the proliferation of spermatogonial stem cells in vitro without inducing apoptosis.

Targeting Thymidine Phosphorylase with Tipiracil Hydrochloride is a Safe and Effective Antithrombotic Therapy

This study shows that TPI, a TYMP inhibitor, safely and effectively inhibits platelet activation and thrombosis in vitro and in vivo.

Perturbation of GABA Biosynthesis Links Cell Cycle to Control Arabidopsis thaliana Leaf Development

This paper investigates how perturbing GABA biosynthesis in Arabidopsis affects leaf development by linking it to endoreplication and cell expansion.