Disruption of the SYNGAP1 PDZ ligand motif accelerates differentiation of human iPSC-derived GABAergic neurons
J. P. Jiang, Ruslan Rust, Ilse Flores, Yaowen Feng, Peyman Nouri, Veronica A. Clementel, Amir Arya, Ali Basirattalab, Ivy Y. Yang, Antigoni Manousopoulou, Spiros D. Garbis, Nicholas Alexander Graham, Marcelo P. Coba
This study shows that disrupting the SYNGAP1 PDZ ligand motif speeds up differentiation of human iPSC-derived GABAergic neurons, revealing its role in neuronal maturation.
bioRxiv · Feb 25, 2026 · PreprintNeuroscience