Author

Roger E. Moore

City Of Hope National Medical CenterORCID 0000-0002-8907-2144Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Patrick PirrotteiD· 2 shared Alexander AtamianiD· 1 shared Amy LeungiD· 1 shared Ashley Del Dosso· 1 shared Brent WilkinsoniD· 1 shared Camilo RojasiD· 1 shared Dimitri LiniD· 1 shared Dustin E. SchonesiD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Patrick PirrotteORCID

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2 papers

Recent·Most cited

Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome

Heon Shin, Amy Leung, Kevin R Costello, Parijat Senapati, Hiroyuki Kato, Roger E. Moore, Michael Lee, Dimitri Lin, Xiaofang Tang, Patrick Pirrotte, Zhen Chen, Dustin E. Schones

This study shows that glucose-regulated O-GlcNAcylation of DNMT1 inhibits its methyltransferase activity, leading to epigenome changes and increased DNA damage.

eLife · Jul 20, 2023Peer-reviewedMolecular Biology

The autism-associated gene SYNGAP1 regulates human cortical neurogenesis

Marcella Birtele, Ashley Del Dosso, Tiantian Xu, Tuan N. Nguyen, Brent Wilkinson, Negar Hosseini, Sarah C. Nguyen, Jean‐Paul Urenda, Gavin T. Knight, Camilo Rojas, Ilse Flores, Alexander Atamian, Roger E. Moore, Ritin Sharma, Patrick Pirrotte, , Giorgia Quadrato

This study shows SYNGAP1, an autism risk gene, is expressed in human cortical progenitors and its dysfunction disrupts neurogenesis and cortical lamination.

bioRxiv · May 10, 2022 · PreprintDevelopmental Biology