Author

Rico J. E. Derks

Leiden University Medical CenterORCID 0000-0002-8920-7133Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Martin A. GieraiD· 3 shared Alessandro Ori‬‬iD· 2 shared Damien Olivier‐JimeneziD· 2 shared Yassene MohammediD· 2 shared Adrian M. IsaacsiD· 1 shared Alexander J. CammackiD· 1 shared Andy Henrie· 1 shared Annemarie M. A. de Graaf· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersNeuroscience

Martin A. GieraORCID

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Author profile →

3 papers

Recent·Most cited

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4

Femke M. Feringa, Sascha Koppes-den Hertog, Lian Y. Wang, Rico J. E. Derks, Iris Daphne Kruijff, Lena Erlebach, Jorin Heijneman, Ricardo Miramontes, Nadine Pömpner, Niek Blomberg, Damien Olivier‐Jimenez, Lill Eva Johansen, Alexander J. Cammack, Ashling Giblin, Christina E. Toomey, , Rik van der Kant

The paper introduces the Neurolipid Atlas, a lipidomics resource for neurodegenerative diseases, revealing that ApoE4 impairs astrocyte reactivity by promoting cholesterol ester accumulation.

Nature Metabolism · Sep 22, 2025Peer-reviewedNeuroscience

Normothermic human kidney preservation drives iron accumulation and ferroptosis

Marlon J.A. de Haan, Marleen E Jacobs, Annemarie M. A. de Graaf, Roan H van Scheppingen, Rico J. E. Derks, Dorottya K. de Vries, Jesper Kers, Ian P.J. Alwayn, Cees van Kooten, Elena Sánchez‐López, Martin A. Giera, Marten A. Engelse, Ton J. Rabelink

This study shows that normothermic kidney preservation with red blood cells causes iron accumulation and ferroptosis, leading to kidney injury, and suggests alternatives to mitigate these effects.

Nature Communications · Jul 1, 2025Peer-reviewedPhysiology

iSODA: A Comprehensive Tool for Integrative Omics Data Analysis in Single- and Multi-Omics Experiments

Damien Olivier‐Jimenez, Rico J. E. Derks, Oscar Harari, Carlos Cruchaga, Muhammad Ali, Alessandro Ori‬‬, Domenico Di Fraia, Birol Cabukusta, Andy Henrie, Martin A. Giera, Yassene Mohammed

iSODA is a web-based tool for analyzing single- and multi-omics data, offering visualization, normalization, and integration methods like MOFA and SNF.

Analytical Chemistry · Jan 31, 2025Peer-reviewedBioinformatics