Author

J. B. G. Mackey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1

Frequent Co-Authors

A. J. McFarlane· 3 shared F. Fercoq· 3 shared J. Secklehner· 3 shared A. Hedley· 2 shared C. Nixon· 2 shared D. J. Murphy· 2 shared G. J. Graham· 2 shared J. Vuononvirta· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersImmunology

A. J. McFarlane

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

γδ T cells impair airway macrophage differentiation in lung adenocarcinoma

X. L. Raffo-Iraolagoitia, A. J. McFarlane, B. Kruspig, F. Fercoq, J. Secklehner, M. De Donatis, J. B. G. Mackey, R. Wiesheu, S. Laing, Y.-C. Hsieh, R. Shaw, R. Corbyn, C. Nixon, C. Miller, K. Kirschner, , L. M. Carlin

The paper identifies that CD27+ γδ T cells impair the differentiation of tumor-associated macrophages into airway macrophages in lung adenocarcinoma.

bioRxiv · Sep 14, 2023Immunology

CXCR2 inhibition enables NASH-HCC immunotherapy

J. Leslie, J. B. G. Mackey, T. Jamieson, E. Ramon-Gil, T. M. Drake, F. Fercoq, W. Clark, K. Gilroy, A. Hedley, C. Nixon, S. Luli, M. Laszczewska, R. Pinyol, R. Esteban-Fabro, C. E. Willoughby, , Carlin

This study shows that combining CXCR2 inhibition with anti-PD1 therapy enhances immunotherapy response in NASH-HCC by reprogramming tumor-associated neutrophils.

bioRxiv · Feb 24, 2022Cancer Biology

Maturation, developmental site, and pathology dictate murine neutrophil function

J. B. G. Mackey, A. J. McFarlane, T. Jamieson, R. Jackstadt, X. L. Raffo-Iraolagoitia, J. Secklehner, X. Cortes-Lavaud, F. Fercoq, W. Clarke, A. Hedley, K. Gilroy, S. Lilla, J. Vuononvirta, G. J. Graham, K. De Filippo, , L. M. Carlin

This study identifies Ly6G expression levels as a marker for neutrophil maturation stages and shows spleen-derived neutrophils mature faster with distinct transcriptional profiles.

bioRxiv · Jul 21, 2021 · PreprintImmunology

Pulmonary natural killer cells control neutrophil intravascular motility and response to acute inflammation

J. Secklehner, K. De Filippo, J. B. G. Mackey, J. Vuononvirta, X. L. Raffo Iraolagoitia, A. J. McFarlane, M. Neilson, M. B. Headley, M. F. Krummel, N. Guerra, L. Carlin

This study shows pulmonary natural killer cells reduce neutrophil accumulation during inflammation by altering their motility.

bioRxiv · Jun 23, 2019 · PreprintImmunology