Author

A. J. McFarlane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

F. Fercoq· 3 shared J. B. G. Mackey· 3 shared J. Secklehner· 3 shared L. M. Carlin· 3 shared X. L. Raffo-Iraolagoitia· 3 shared C. Nixon· 2 shared D. J. Murphy· 2 shared J. C. Norman· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersImmunology

F. Fercoq

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer

F. Fercoq, G. S. Cairns, M. De Donatis, J. B. Mackey, A. Floerchinger, A. J. McFarlane, X. L. Raffo-Iraolagoitia, D. Whyte, L. W. Arnott, C. Nixon, R. Wiesheu, L. Brown, S. Al-Khalidi, J. C. Norman, E. W. Roberts, , L. M. Carlin

This study shows that integrin conformation-dependent neutrophil slowing in pre-metastatic lungs obstructs capillaries and may contribute to immunosuppression in breast cancer.

bioRxiv · Mar 19, 2024Immunology

γδ T cells impair airway macrophage differentiation in lung adenocarcinoma

X. L. Raffo-Iraolagoitia, A. J. McFarlane, B. Kruspig, F. Fercoq, J. Secklehner, M. De Donatis, J. B. G. Mackey, R. Wiesheu, S. Laing, Y.-C. Hsieh, R. Shaw, R. Corbyn, C. Nixon, C. Miller, K. Kirschner, , L. M. Carlin

The paper identifies that CD27+ γδ T cells impair the differentiation of tumor-associated macrophages into airway macrophages in lung adenocarcinoma.

bioRxiv · Sep 14, 2023Immunology

Maturation, developmental site, and pathology dictate murine neutrophil function

J. B. G. Mackey, A. J. McFarlane, T. Jamieson, R. Jackstadt, X. L. Raffo-Iraolagoitia, J. Secklehner, X. Cortes-Lavaud, F. Fercoq, W. Clarke, A. Hedley, K. Gilroy, S. Lilla, J. Vuononvirta, G. J. Graham, K. De Filippo, , L. M. Carlin

This study identifies Ly6G expression levels as a marker for neutrophil maturation stages and shows spleen-derived neutrophils mature faster with distinct transcriptional profiles.

bioRxiv · Jul 21, 2021 · PreprintImmunology

Pulmonary natural killer cells control neutrophil intravascular motility and response to acute inflammation

J. Secklehner, K. De Filippo, J. B. G. Mackey, J. Vuononvirta, X. L. Raffo Iraolagoitia, A. J. McFarlane, M. Neilson, M. B. Headley, M. F. Krummel, N. Guerra, L. Carlin

This study shows pulmonary natural killer cells reduce neutrophil accumulation during inflammation by altering their motility.

bioRxiv · Jun 23, 2019 · PreprintImmunology