B. M. Mortzfeld

Microbiota encoded fatty-acid metabolism expands tuft cells to protect tissues homeostasis during Clostridioides difficile infection in the large intestine

This study shows that succinate from the microbiota expands tuft cells in the colon, enhancing type 2 immunity and reducing C. difficile-induced disease.

Expanding the toolbox: Novel class IIb microcins show activity against gram-negative ESKAPE and plant pathogens

The paper identifies twelve new class IIb microcins from seven Enterobacteriaceae species and validates their activity against Gram-negative pathogens and plant pathogens.

Recurrent phases of strict protein limitation inhibit tumor growth and restore lifespan in a Drosophila intestinal cancer model

The paper shows that cyclic severe protein restriction in Drosophila reduces tumor growth, restores gut function, and extends lifespan without the harmful effects of continuous restriction.

Microcin MccI47 selectively inhibits enteric bacteria and reduces carbapenem-resistant Klebsiella pneumoniae colonization in vivo when administered via an engineered live biotherapeutic

This paper demonstrates that engineered live biotherapeutic Escherichia coli producing microcin MccI47 reduces carbapenem-resistant Klebsiella pneumoniae colonization in mice without disrupting the microbiota.

Proanthocyanidin-enriched cranberry extract induces resilient bacterial community dynamics in a gnotobiotic mouse model

This study shows that a proanthocyanidin-enriched cranberry extract alters bacterial community dynamics in a gnotobiotic mouse model, with transient increases in mucin-degrading and anti-inflammatory bacteria.