Author

J. C. Howard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1

Frequent Co-Authors

A. F. Arenas Soto· 1 shared A. Hessel· 1 shared A. M. Bastidas Quintero· 1 shared B. Saller· 1 shared C. Campos· 1 shared E. Eren· 1 shared E. Meunier· 1 shared G. A. Taylor· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

A. F. Arenas Soto

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Dual role of Toxoplasma gondii ROP5 and ROP18 for NLRP3 inhibition

M. Murillo-Leon, A. M. Bastidas Quintero, S. Singh, X. Mueller, O. Gorka, B. Saller, A. F. Arenas Soto, C. Campos, J. E. Gomez-Marin, O. Gross, K. Pfeffer, J. C. Howard, G. A. Taylor, T. Steinfeldt

This paper identifies vacuolar disruption as a trigger for NLRP3 inflammasome activation in Toxoplasma gondii infection and shows ROP5 and ROP18 inhibit IL-1β release by protecting the parasitophorous vacuole and interacting with GBP5.

bioRxiv · Sep 17, 2023 · PreprintMicrobiology

Irgm2 and Gate-16 cooperatively dampen targeting of caspase-11 to Gram-negative bacterial products

E. Eren, R. Planes, S. Bagayoko, P.-J. Bordignon, K. Chaoui, A. Hessel, K. Santoni, M. Pinilla, O. Schiltz, J. C. Howard, M. Yamamoto, E. Meunier

This study identifies Irgm2 and Gate-16 as cooperative regulators that dampen non-canonical inflammasome activation by reducing caspase-11 targeting to intracellular bacteria.

bioRxiv · Mar 6, 2020Immunology